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Pathological Role of Inflammation in Ocular Disease Progress and Its Targeting by Mesenchymal Stem Cells (Mscs) and Their Exosome; Current Status and Prospect Publisher Pubmed



Nouralishahi A1, 2 ; Fazlinejad N3 ; Pecho RDC4 ; Zaidan HK5 ; Kheradjoo H6 ; Amin AH7 ; Mohammadzadehsaliani S8
Authors
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Authors Affiliations
  1. 1. Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. KIMS Hospital, Oman
  3. 3. Khodadoust Eye Hospital, Shiraz, Iran
  4. 4. Department of Biochemistry, Universidad San Ignacio de Loyola (USIL), Lima, Peru
  5. 5. Department of Medical Laboratories Techniques, Al-Mustaqbal University College, Babylon, Hillah, Iraq
  6. 6. Laboratory Department, Buraimi Hospital, Buraimi, Oman
  7. 7. Zoology Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt
  8. 8. Ophthalmology Department, Buraimi Hospital, Buraimi, Oman

Source: Pathology Research and Practice Published:2023


Abstract

Because of their unique capacity for differentiation to a diversity of cell lineages and immunosuppressive properties, mesenchymal stem cells (MSC) are being looked at as a potential new treatment option in ophthalmology. The MSCs derived from all tissue sources possess immunomodulatory attributes through cell-to-cell contact and releasing a myriad of immunomodulatory factors (IL-10, TGF-β, growth-related oncogene (GRO), indoleamine 2,3 dioxygenase (IDO), nitric oxide (NO), interleukin 1 receptor antagonist (IL-1Ra), prostaglandin E2 (PGE2)). Such mediators, in turn, alter both the phenotype and action of all immune cells that serve a pathogenic role in the progression of inflammation in eye diseases. Exosomes from MSCs, as natural nano-particles, contain the majority of the bioactive components of parental MSCs and can easily by-pass all biological barriers to reach the target epithelial and immune cells in the eye without interfering with nearby parenchymal cells, thus having no serious side effects. We outlined the most recent research on the molecular mechanisms underlying the therapeutic benefits of MSC and MSC-exosome in the treatment of inflammatory eye diseases in the current article. © 2023
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