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Glomerular Hyperfiltration As Predictor of Cardiometabolic Risk Factors Among Children and Adolescents: The Childhood and Adolescence Surveillance and Prevention of Adult⇑V Study Publisher



Kelishadi R1 ; Qorbani M2, 3 ; Assadi F4 ; Esmaeil Motlagh M5 ; Djalalinia S6 ; Shahsavari A1 ; Ziaodini H7 ; Taheri M8 ; Shafiee G3 ; Aminianfar A9 ; Esmaeili S1 ; Aminaei T8 ; Mansourian M10 ; Heshmat R3
Authors
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Authors Affiliations
  1. 1. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non‑communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Non‑communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pediatrics, Division of Nephrology, Rush University Medical Center, Chicago, IL, United States
  5. 5. Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Development of Research Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
  7. 7. Department of Health, Bureau of Health and Fitness, Ministry of Education and Training, Tehran, Iran
  8. 8. Department of Epidemiology, Office of Adolescents and School Health, Ministry of Health and Medical Education, Tehran, Iran
  9. 9. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: International Journal of Preventive Medicine Published:2018


Abstract

Background: The prevalence of glomerular hyperfiltration and chronic kidney disease is increasing worldwide in parallel with obesity hypertension epidemic. The effect of increases in glomerular filtrations (GFR) in children with metabolic syndrome has not been studied. The purpose of the present study is to investigate the relationship between GFR and cardiometabolic risk factors in a large sample of pediatric population. Methods: In this nationwide survey, 3800 participants were selected by cluster random sampling from 30 provinces in Iran. Anthropometric measures, biochemical, and clinical parameters were measured. We also measured estimated GFR (eGFR) using the recently modified Schwartz equations and other known cardiometabolic risk factors such as elevated total cholesterol, high low‑density lipoprotein cholesterol (LDL‑C), and obesity. Results: The response rate was 91.5% (n = 3843). The mean and standard deviation (SD) (Mean ± SD) of eGFR for girls, boys, and total population were 96.71 ± 19.46, 96.49 ± 21.69, and 96.59 ± 20 ml/min/1.73 m2, respectively. Overall, 38.7% of the participants did not have any cardiometabolic risk factor. In multivariate models, the risk of elevated systolic blood pressure (BP) (odds ratio [OR]: 1.48; 95% confidence interval [CI]: 1.08-2.02), elevated diastolic BP (OR: 1.48; 95% CI: 1.08-2.02), elevated LDL‑C (OR: 1.35; 95% CI: 1.07-1.70), and obesity (OR: 1.70; 95%CI: 1.24-2.33) were significantly higher in participants with higher eGFR level than those with the lower level but not with low level of high‑density lipoprotein cholesterol (OR: 0.72; 95% CI: 0.60-0.88). Conclusions: This study demonstrates an association between glomerular hyperfiltration and obesity‑related hypertension in a large sample of the Iranian pediatric population, independently of other classical risk factors. © 2018 International Journal of Preventive Medicine.
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