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Impact of Dyslipidemia on Estimated Glomerular Filtration Rate in Apparently Healthy Children and Adolescents: The Caspian-V Study Publisher Pubmed



Moafi M1 ; Assadi F2 ; Heshmat R3 ; Khoshhali M4 ; Qorbani M5 ; Motlagh ME6 ; Dashti R7 ; Taheri M8 ; Kelishadi R9
Authors
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Authors Affiliations
  1. 1. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pediatric Nephrology, Rush University Medical Center, 445 E. North Water Street, Suite 1804, Chicago, 60611, IL, United States
  3. 3. Department of Epidemiology, Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biostatistics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Epidemiology, Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. 7. Bureau of Family, Population, Youth and School Health, Ministry of Health and Medical Education, Tehran, Iran
  8. 8. Population, Youth and School Health, Ministry of Health and Medical Education, Tehran, Iran
  9. 9. Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: World Journal of Pediatrics Published:2019


Abstract

Background: Chronic kidney disease (CKD) is a leading risk factor for development of cardiovascular disease (CVD). Dyslipidemia is also known as risk factor for CVD development. However, the association of dyslipidemia with glomerular injury among healthy children and adolescents remains controversial. We aimed to investigate the relationship between estimated glomerular filtration rate (eGFR) and lipid profile risk factors among healthy children and adolescents. Methods: In this nationwide survey, 3808 participants (1992 males, 1816 females), aged 7–18 years, were selected by cluster random sampling method from 30 provinces in Iran. Body mass index (BMI) and systolic and diastolic blood pressures were measured. Blood samples were obtained for serum creatinine, fasting blood glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) determinations. GFR was estimated using Schwartz equation. Results: Girls had higher eGFR than boys (P = 0.04). In a multiple regression analysis, eGFR demonstrated a positive correlation with systolic blood pressure, BMI, fasting glucose, TC, HDL-C, and TG. By the analysis of covariance, TC, HDL-C, and TG showed a negative correlation with eGFR after adjustments for BMI, systolic and diastolic blood pressures, and fasting glucose (OR = 0.56, 95% CI = 0.29–0.89). Conclusion: The study showed that dyslipidemia is associated with reduced eGFR among the healthy children and adolescents. © 2019, Children's Hospital, Zhejiang University School of Medicine.
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