Population Structures of Leishmania Infantum and Leishmania Tropica the Causative Agents of Kala-Azar in Southwest Iran

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Population Structures of Leishmania Infantum and Leishmania Tropica the Causative Agents of Kala-Azar in Southwest Iran Publisher Pubmed

Ghatee MA^{1, 2} ; Mirhendi H³ ; Karamian M^{4, 5} ; Taylor WR^{6, 7} ; Sharifi I⁸ ; Hosseinzadeh M⁹ ; Kanannejad Z¹⁰

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1. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
2. Department of Parasitology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
3. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
5. Infectious Diseases Research Centre, Birjand University of Medical Sciences, Birjand, Iran
6. Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand
7. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
8. Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
9. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
10. Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Parasitology Research Published:2018

Abstract

Visceral leishmaniasis (VL) is endemic in Iran and is caused predominantly by Leishmania infantum, but L. tropica is emerging as an important cause. We studied the intra-species population structure of Leishmania spp. causing VL in southwest Iran by sequence analysis of the internal transcribed spacer (ITS) 1 of DNA samples from 29 bone marrow aspiration smears. L. infantum (n = 25) and L. tropica (n = 4) were identified, consisting of 10 and three ITS1 sequence types (STs), respectively. Compared to GenBank ITS1 STs, our L. infantum parasites displayed high heterogeneity but less heterogeneity compared than northwest Iranian isolates. VL affects mostly nomadic populations in southwest Iran, and their mobility may explain partly the L. infantum heterogeneity. The VL causing L. tropica was also genetically heterogeneous but genetically indistinguishable from L. tropica strains causing anthroponotic cutaneous leishmaniasis from southwest Iran. © 2018, The Author(s).

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Style	Citing Format
MLA	Ghatee MA, et al.. "Population Structures of Leishmania Infantum and Leishmania Tropica the Causative Agents of Kala-Azar in Southwest Iran." Parasitology Research, vol. 117, no. 11, 2018, pp. 3447-3458.
APA	Ghatee MA, Mirhendi H, Karamian M, Taylor WR, Sharifi I, Hosseinzadeh M, Kanannejad Z (2018). Population Structures of Leishmania Infantum and Leishmania Tropica the Causative Agents of Kala-Azar in Southwest Iran. Parasitology Research, 117(11), 3447-3458.
Chicago	Ghatee MA, Mirhendi H, Karamian M, Taylor WR, Sharifi I, Hosseinzadeh M, Kanannejad Z. "Population Structures of Leishmania Infantum and Leishmania Tropica the Causative Agents of Kala-Azar in Southwest Iran." Parasitology Research 117, no. 11 (2018): 3447-3458.
Harvard	Ghatee MA et al. (2018) 'Population Structures of Leishmania Infantum and Leishmania Tropica the Causative Agents of Kala-Azar in Southwest Iran', Parasitology Research, 117(11), pp. 3447-3458.
Vancouver	Ghatee MA, Mirhendi H, Karamian M, Taylor WR, Sharifi I, Hosseinzadeh M, et al.. Population Structures of Leishmania Infantum and Leishmania Tropica the Causative Agents of Kala-Azar in Southwest Iran. Parasitology Research. 2018;117(11):3447-3458.
BibTex	@article{ author = {Ghatee MA and Mirhendi H and Karamian M and Taylor WR and Sharifi I and Hosseinzadeh M and Kanannejad Z}, title = {Population Structures of Leishmania Infantum and Leishmania Tropica the Causative Agents of Kala-Azar in Southwest Iran}, journal = {Parasitology Research}, volume = {117}, number = {11}, pages = {3447-3458}, year = {2018} }
RIS	TY - JOUR AU - Ghatee MA AU - Mirhendi H AU - Karamian M AU - Taylor WR AU - Sharifi I AU - Hosseinzadeh M AU - Kanannejad Z TI - Population Structures of Leishmania Infantum and Leishmania Tropica the Causative Agents of Kala-Azar in Southwest Iran JO - Parasitology Research VL - 117 IS - 11 SP - 3447 EP - 3458 PY - 2018 ER -

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