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Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts Publisher Pubmed



Avagimyan A1 ; Fogacci F2 ; Pogosova N3 ; Kakrurskiy L4 ; Kogan E5 ; Urazova O6 ; Kobalava Z7 ; Mikhaleva L4 ; Vandysheva R4 ; Zarina G4 ; Trofimenko A8 ; Navasardyan G9 ; Mkrtchyan L10 ; Galli M11 Show All Authors
Authors
  1. Avagimyan A1
  2. Fogacci F2
  3. Pogosova N3
  4. Kakrurskiy L4
  5. Kogan E5
  6. Urazova O6
  7. Kobalava Z7
  8. Mikhaleva L4
  9. Vandysheva R4
  10. Zarina G4
  11. Trofimenko A8
  12. Navasardyan G9
  13. Mkrtchyan L10
  14. Galli M11
  15. Jndoyan Z12
  16. Aznauryan A13
  17. Saahakyan K14
  18. Agati L14
  19. Shafie D15
  20. Cicero A2
  21. Di Salvo G16
  22. Sarrafzadegan N17
Show Affiliations
Authors Affiliations
  1. 1. Anatomical Pathology and Clinical Morphology Department, Yerevan State Medical University, Yerevan, Armenia
  2. 2. Atherosclerosis and Metabolic Disorders Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy
  3. 3. Research and Preventive Cardiology, National Medical Research Centre of Cardiology, Moscow, Russian Federation
  4. 4. A.P. Avtsyn Research Institute of Human Morphology FSBI “Petrovskiy NRCS” Moscow, Russian Federation
  5. 5. Pathology Department, Immunohistochemistry Reference Centre of Institute of Clinical Morphology and Digital Pathology, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
  6. 6. Pathophysiology Department, Siberian State Medical University, Tomsk, Russian Federation
  7. 7. Internal Disease and Cardiology Department, Peoples Friendship University of Russia, Moscow, Russian Federation
  8. 8. Pathophysiology Department, Kuban State Medical University, Krasnodar, Russian Federation
  9. 9. Pathophysiology Department, Yerevan State Medical University, Yerevan, Armenia
  10. 10. Cardiology Department, Yerevan State Medical University, Yerevan, Armenia
  11. 11. Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
  12. 12. Internal Diseases Propaedeutic Department, Yerevan State Medical University, Yerevan, Armenia
  13. 13. Histology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  14. 14. Cardiology Department, Azienda Umberto I, Sapienza University, Rome, Italy
  15. 15. Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran
  16. 16. Imperial College of London, London, United Kingdom
  17. 17. Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Current Problems in Cardiology Published:2024


Abstract

Diabetes mellitus (DM) is considered by many the pandemic of the 21st century and is associated with multiple organ damages. Among these, cardiovascular complications are responsible for an incredible burden of mortality and morbidity in Western Countries. The study of the pathological mechanisms responsible for the cardiovascular complications in DM patients is key for the development of new therapeutic strategies. The metabolic disorders caused by hyperglycemia, insulin resistance, and dyslipidemia, results in a cascade of pathomorphological changes favoring the atherosclerotic process and leading to myocardial remodeling. Parallel to this, oxidative stress, calcium overload, mitochondrial dysfunction, activation of protein kinase C signaling pathways, myocardial lipomatosis, and low-grade inflammation of the myocardium - are the main pathways responsible for the diabetic cardiomyopathy development. This review aims to appraise and discuss the pathogenetic mechanisms behind the diabetic cardiomyopathy development. © 2023 Elsevier Inc.
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