Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Role of P66shc in Diabetes: A Comprehensive Review From Bench to Bedside Publisher Pubmed



Mousavi S1, 2 ; Khazeei Tabari MA3, 4 ; Bagheri A2, 5 ; Samieefar N1, 2 ; Shaterian N6, 7 ; Kelishadi R8, 9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, Mazandaran University of Medical Sciences, Mazandaran, Iran
  4. 4. USERN Office, Mazandaran University of Medical Sciences, Mazandaran, Iran
  5. 5. Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran
  6. 6. Student Research Committee, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
  7. 7. USERN Office, Jahrom University of Medical Sciences, Jahrom, Iran
  8. 8. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. USERN Office, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Diabetes Research Published:2022


Abstract

It is well-documented that diabetes is an inflammatory and oxidative disease, with an escalating global burden. Still, there is no definite treatment for diabetes or even prevention of its harmful complications. Therefore, understanding the molecular pathways associated with diabetes might help in finding a solution. p66Shc is a member of Shc family proteins, and it is considered as an oxidative stress sensor and regulator in cells. There are inconsistent data about the role of p66Shc in inducing diabetes, but accumulating evidence supports its role in the pathogenesis of diabetes-related complications, including macro and microangiopathies. There is growing hope that by understanding and targeting molecular pathways involved in this network, prevention of diabetes or its complications would be achievable. This review provides an overview about the role of p66Shc in the development of diabetes and its complications. © 2022 SeyedehFatemeh Mousavi et al.
Related Docs
View other Related Docs
1. Therapeutic Potential of Resveratrol in Diabetic Nephropathy According to Molecular Signaling, Current Molecular Pharmacology (2022)
2. Role of Oxidative Stress and Inflammatory Factors in Diabetic Kidney Disease, Iranian Journal of Kidney Diseases (2016)
3. An Update on Diabetic Kidney Disease, Oxidative Stress and Antioxidant Agents, Journal of Renal Injury Prevention (2017)
4. Crosstalk Between Autophagy and Insulin Resistance: Evidence From Different Tissues, European Journal of Medical Research (2023)
5. Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts, Current Problems in Cardiology (2024)
6. Bright Renoprotective Properties of Metformin: Beyond Blood Glucose Regulatory Effects, Iranian Journal of Kidney Diseases (2013)
7. Non-Invasive Metabolic Biomarkers for Early Diagnosis of Diabetic Nephropathy: Meta-Analysis of Profiling Metabolomics Studies, Nutrition, Metabolism and Cardiovascular Diseases (2021)
8. Ipp-1 Controls Akt/Creb Phosphorylation Extension in A2a Adenosine Receptor Signaling Cascade in Min6 Pancreatic Β-Cell Line, European Journal of Pharmacology (2019)
Experts (# of related papers)
View all Related Experts
Fouzieh Zadhoush (4)
Nepton Soltani (4)
Other Related Docs
9. Effects of Oral Butyrate and Inulin Supplementation on Inflammation-Induced Pyroptosis Pathway in Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Cytokine (2020)
10. Pramlintide: An Amylin Analogue Protects Endothelial Cells Against Oxidative Stress Through Regulating Oxidative Markers and Nf-Κb Expression, International Journal of Preventive Medicine (2022)
11. Effect of Oral Magnesium Sulfate Administration on Blood Glucose Hemostasis Via Inhibition of Gluconeogenesis and Foxo1 Gene Expression in Liver and Muscle in Diabetic Rats, Biomedicine and Pharmacotherapy (2019)
12. Oxidant/Antioxidant Status in Type-2 Diabetes Mellitus Patients With Metabolic Syndrome, Journal of Research in Medical Sciences (2021)
13. Nigella Sativa in Controlling Type 2 Diabetes, Cardiovascular, and Rheumatoid Arthritis Diseases: Molecular Aspects, Journal of Research in Medical Sciences (2021)
14. Antioxidant Effects of Astaxanthin and Metformin Combined Therapy in Type 2 Diabetes Mellitus Patients: A Randomized Double-Blind Controlled Clinical Trial, Research in Pharmaceutical Sciences (2022)
15. Effect of Peroxisome Proliferator-Activated Receptor Agonists on Serum Inflammatory Markers in Diabetic Rats, Journal of Isfahan Medical School (2014)
16. Toll-Like Receptors and Diabetic Nephropathy: A Review of Recent Advances, Turkish Journal of Immunology (2024)
17. Effects of Pistacia Atlantica on Oxidative Stress Markers and Antioxidant Enzymes Expression in Diabetic Rats, Journal of the American College of Nutrition (2019)
18. Comparison of Oxidative Stress Indices in Pregnant Women With and Without Gestational Diabetes Mellitus, Journal of Isfahan Medical School (2019)
19. Beneficial Effects of Mgso4 on Tfam, Upc3 and Fndc5 Mrna Expressions in Skeletal Muscle of Type 2 Diabetic Rats: A Possible Mechanism to Improve Insulin Resistance, Molecular Biology Reports (2022)
20. Sulfaphenazole Treatment Restores Endothelium-Dependent Vasodilation in Diabetic Mice, Vascular Pharmacology (2008)
21. Polyphenols for Diabetes Associated Neuropathy: Pharmacological Targets and Clinical Perspective, DARU, Journal of Pharmaceutical Sciences (2019)
22. Moderate Exercise Attenuates Caspase-3 Activity, Oxidative Stress, and Inhibits Progression of Diabetic Renal Disease in Db/Db Mice, American Journal of Physiology - Renal Physiology (2009)
23. Possible Mechanisms and Molecular Signaling of Incretins Against the Development of Type 2 Diabetes Mellitus, Current Molecular Pharmacology (2023)
24. Effects of Salvia Mirzayanii Extract Administration on Hyperglycemia Improvement in Diabetic Rats: The Role of Glut4, Pepck and G6pase Genes, Heliyon (2024)
25. Long-Term Gaba Administration Improves Fndc5, Tfam, and Ucp3 Mrna Expressions in the Skeletal Muscle and Serum Irisin Levels in Chronic Type 2 Diabetic Rats, Naunyn-Schmiedeberg's Archives of Pharmacology (2022)
26. The Role of Irisin in Various Organs of the Human Body With Emphasis on the Beneficial Effects on Glucose Homeostasis, Journal of Isfahan Medical School (2022)
27. Effects of Hydroalcoholic Extract of Fumaria Parviflora Lam on Gene Expression and Serum Levels of Inflammatory and Oxidative Stress Parameters in Patients With Type 2 Diabetes: A Randomized Controlled Clinical Trial, Journal of Functional Foods (2024)
28. Molecular Aspects of Pancreatic Β-Cell Dysfunction: Oxidative Stress, Microrna, and Long Noncoding Rna, Journal of Cellular Physiology (2019)