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Genetic Thromboembolic Risk Factors Associated With Deep Vein Thrombosis in a Iranian Population



Mohajer H1 ; Khosravi AR2 ; Saadatnia M3 ; Abdar M2 ; Azarm T1
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: The development of venous thromboembolism is influenced by a variety of genetic and environmental risk factors. A few studies have ascertained whether thrombophilic defects are risk factors for venous thromboembolism in Middle East and Iranian populations or not. Methods: We conducted a case-control study involving 66 consecutive patients with deep vein thrombosis without immobility and 66 healthy controls from the Al-Zahra Hospital in Isfahan, Iran. Finding: The most frequent thrombophilic risk factor for deep vein thrombosis was homocysteine (31/66) (OR = 3.6, 95% CI = (1.66-7.84)). Anticardiolipin antibody was seen in 10.6% (OR =7.71, 95% CI = (0.99-64.55)). There were no significant differences for other risk factor such as Protein S, Protein C, Antithrombin III, Factor V leiden, and Prothrombin mutation. Conclusion: In spite of western studies, Factor V leiden and Prothrombin mutation are rare between Iranian patients. However, homocysteine and anticadiolipin anti bodies are the most frequent risk factors. Screening for Factor V leiden and Prothrombin mutation have not cost benefit and further studies with larger sample size need to detect new mutations and assess the influence of ethnicity on thrombophilia.
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