Genetic Thromboembolic Risk Factors Associated With Deep Vein Thrombosis in a Iranian Population



Mohajer H¹ ; Khosravi AR² ; Saadatnia M³ ; Abdar M² ; Azarm T¹
Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: The development of venous thromboembolism is influenced by a variety of genetic and environmental risk factors. A few studies have ascertained whether thrombophilic defects are risk factors for venous thromboembolism in Middle East and Iranian populations or not. Methods: We conducted a case-control study involving 66 consecutive patients with deep vein thrombosis without immobility and 66 healthy controls from the Al-Zahra Hospital in Isfahan, Iran. Finding: The most frequent thrombophilic risk factor for deep vein thrombosis was homocysteine (31/66) (OR = 3.6, 95% CI = (1.66-7.84)). Anticardiolipin antibody was seen in 10.6% (OR =7.71, 95% CI = (0.99-64.55)). There were no significant differences for other risk factor such as Protein S, Protein C, Antithrombin III, Factor V leiden, and Prothrombin mutation. Conclusion: In spite of western studies, Factor V leiden and Prothrombin mutation are rare between Iranian patients. However, homocysteine and anticadiolipin anti bodies are the most frequent risk factors. Screening for Factor V leiden and Prothrombin mutation have not cost benefit and further studies with larger sample size need to detect new mutations and assess the influence of ethnicity on thrombophilia.