Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Inflammatory Potential of the Diet and Ulcerative Colitis: A Case-Control Study Publisher



Khademi Z1, 2 ; Saneei P3, 4 ; Hassanzadehkeshteli A5, 6 ; Daghaghzadeh H6 ; Tavakkoli H6 ; Adibi P6 ; Esmaillzadeh A2, 4, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Medicine, University of Alberta, Edmonton, AB, Canada
  6. 6. Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Frontiers in Nutrition Published:2021


Abstract

Background/Aim: Despite the inflammatory nature of inflammatory bowel disease (IBD), limited data are available on the association of inflammatory potential of the diet and risk of ulcerative colitis (UC). We aimed to investigate the association of inflammatory potential of the diet (IPD) score and odds of UC in a case-control study. Methods: Patients with UC were enrolled from Iranian IBD registry, whose disease was confirmed by a gastroenterologist. Controls were selected randomly from the Study of the Epidemiology of Psycho Alimentary Health and Nutrition (SEPAHAN) study, a large population-based study on more than 8,000 apparently healthy individuals. Dietary intakes of 28 food items obtained from a validated dish-based food frequency questionnaire (FFQ), were used to compute IPD score. Results: This case-control study was carried out among 109 cases and 218 randomly chosen controls. Mean age of cases and controls was 39.5 ± 10.0 and 41.5 ± 11.8 y, respectively. Totally, 52% of study participants were female and 48% were male. After controlling for age, sex, and body mass index (BMI), we found that the patients with UC were more likely to be in the highest quartile of IPD score compared with controls (OR: 2.83; 95% CI: 1.41–5.69, P-trend < 0.001). This association strengthened after additional adjustment for education, smoking, medical history, and physical activity (OR: 3.48; 95% CI: 1.32–9.10, P-trend = 0.003). When we took dietary habits into account, the association was slightly attenuated (OR: 3.33; 95% CI: 1.20–9.20, P-trend = 0.005). Conclusions: We found that adherence to a pro-inflammatory diet was positively associated with greater odds of UC. Further studies are required to confirm these findings. © Copyright © 2021 Khademi, Saneei, Hassanzadeh-Keshteli, Daghaghzadeh, Tavakkoli, Adibi and Esmaillzadeh.
Related Docs
View other Related Docs
1. Association Between Food-Based Dietary Inflammatory Potential and Ulcerative Colitis: A Case–Control Study, Scientific Reports (2023)
2. Adherence to the Pro-Inflammatory Diet in Relation to Prevalence of Irritable Bowel Syndrome, Nutrition Journal (2019)
3. A Population Based Case–Control Study of Association Between Dietary Calcium Intake and Ulcerative Colitis in Adults, Scientific Reports (2022)
4. Dietary Intake of Total Carbohydrates, Sugar and Sugar-Sweetened Beverages, and Risk of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies, Frontiers in Nutrition (2021)
5. Association Between Dietary Inflammatory Index and Psychological Profile in Adults, Clinical Nutrition (2019)
6. The Relationship Between Dietary Inflammatory Index and Psychosomatic Complaints Profiles: Results From Sepahan Cross-Sectional Study, BioPsychoSocial Medicine (2019)
7. Dietary Inflammatory Index and Risk of Multiple Sclerosis: Findings From a Large Population-Based Incident Case–Control Study, Clinical Nutrition (2020)
8. Empirically Derived Food-Based Inflammatory Potential of the Diet, Irritable Bowel Syndrome, and Its Severity, Nutrition (2019)
Experts (# of related papers)
View all Related Experts
Peyman Adibi (90)
Awat Feizi (44)
Other Related Docs
9. Empirically Derived Food-Based Dietary Inflammatory Index Is Associated With Increased Risk of Psychological Disorders in Women, Nutritional Neuroscience (2021)
10. The Dietary Inflammatory Index Is Positively Associated With Cardiometabolic Risk Parameters in Atherosclerosis Patients, Nutrition Research (2022)
11. Association of Dietary Fiber, Fruit, and Vegetable Consumption With Risk of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis, Advances in Nutrition (2021)
12. The Association Between Dietary Patterns and the Risk of Developing Ulcerative Colitis, Clinical Nutrition ESPEN (2022)
13. Association of Dietary Inflammatory Potential With Cardiometabolic Risk Factors and Diseases: A Systematic Review and Dose–Response Meta-Analysis of Observational Studies, Diabetology and Metabolic Syndrome (2020)
14. Association of Ultra-Processed Food Intake With Risk of Inflammatory Bowel Disease: Prospective Cohort Study, The BMJ (2021)
15. Association Between the Dietary Inflammatory Index and Common Mental Health Disorders Profile Scores, Clinical Nutrition (2019)
16. Dietary Inflammatory Index and Its Association With the Risk of Cardiovascular Diseases, Metabolic Syndrome, and Mortality: A Systematic Review and Meta-Analysis, Hormone and Metabolic Research (2018)
17. The Association of Dietary Inflammatory Index and Cognitive Function in Iranian Elders, Recent Advances in Food, Nutrition and Agriculture (2024)
18. The Association Between Dietary Inflammatory Index With Risk Rheumatoid Arthritis: A Case-Control Study, Prostaglandins and Other Lipid Mediators (2024)
19. Association of Dietary Inflammatory Potential (Dip) and Endothelial Function Biomarkers Among Females, Nutrition and Food Science (2022)
20. Inflammatory Potential of Diet and Odds of Lung Cancer: A Case-Control Study, Nutrition and Cancer (2022)
21. Association Between the Dietary Inflammatory Index and Obesity in Otherwise Healthy Adults: Role of Age and Sex, International Journal of Clinical Practice (2021)
22. The Association Between the Dietary Inflammatory Index and Glioma: A Case-Control Study, Clinical Nutrition (2020)
23. Association Between Inflammatory Potential of Diet and Markers of Malnutrition in Haemodialysis Patients, British Journal of Nutrition (2023)
24. The Association of Meal-Specific Food-Based Dietary Inflammatory Index With Cardiovascular Risk Factors and Inflammation in a Sample of Iranian Adults, BMC Endocrine Disorders (2023)
25. The Association Between the Dietary Inflammatory Index and Multiple Myeloma: A Case–Control Study, Scientific Reports (2025)
26. Association of Dietary Inflammatory Index With Anthropometric Indices in Children and Adolescents: The Weight Disorder Survey of the Childhood and Adolescence Surveillance and Prevention of Adult Non-Communicable Disease (Caspian)-Iv Study, British Journal of Nutrition (2019)
27. Is There a Link Between the Inflammatory Potential of a Diet and Mental Health Among Patients With Migraine? Findings From a Cross-Sectional Survey, Nutritional Neuroscience (2024)
28. The Association Between Dietary Inflammatory Index (Dii) and Risk of Hypertension: A Case–Control Study, High Blood Pressure and Cardiovascular Prevention (2022)
29. Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term Nsaids With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (Pure) Study, Clinical Gastroenterology and Hepatology (2023)
30. Effects of Comprehensive Dietary Advice on the Physical and Mental Health of Patients With Ulcerative Colitis During the Remission Phase: A Parallel Randomized Controlled Clinical Trial, International Journal of Food Properties (2020)
31. The Association Between Dietary Inflammatory Index With Risk of Coronavirus Infection and Severity: A Case-Control Study, International Journal of Preventive Medicine (2023)
32. Dietary Magnesium Intake Is Inversely Associated With Ulcerative Colitis: A Case–Control Study, Crohn's and Colitis 360 (2024)
33. Iranian Registry of Crohn’S and Colitis: Study Profile of First Nation-Wide Inflammatory Bowel Disease Registry in Middle East, Intestinal Research (2019)
34. Food Item Avoidance of Patients With Irritable Bowel Syndrome Compared With Healthy People, Archives of Iranian Medicine (2019)
35. The Association Between Dietary Inflammatory Index With Some Cardio-Metabolic Risk Indices Among the Patients With Type 2 Diabetes From Hoveyzeh Cohort Study: A Cross-Sectional Study, BMC Endocrine Disorders (2024)
36. The Association Between Dietary Inflammatory Potential and Gastric Cancer: A Case Control Study, Nutrition and Cancer (2022)
37. Association Between Dietary Inflammatory Index and Phase Angle in University Employees: A Cross-Sectional Study, Scientific Reports (2024)
38. Dietary Inflammatory Potential in Relation to General and Abdominal Obesity, International journal of clinical practice (2022)
39. The Association Between Dietary Acid Load and Odds and Severity of Irritable Bowel Syndrome in Adults, Scientific Reports (2022)
40. The Association Between Dietary Total Antioxidant Capacity and Odds and Severity of Irritable Bowel Syndrome Among Iranian Adults: A Cross-Sectional Study, BMC Gastroenterology (2022)
41. Dietary Patterns and Prevalence of Irritable Bowel Syndrome in Iranian Adults, Neurogastroenterology and Motility (2016)
42. Effects of Dietary Whole Grain, Fruit, and Vegetables on Weight and Inflammatory Biomarkers in Overweight and Obese Women, Eating and Weight Disorders (2020)
43. The Association of Ultra-Processed Food Consumption With Adult Inflammatory Bowel Disease Risk: A Systematic Review and Dose-Response Meta-Analysis of 4 035 694 Participants, Nutrition Reviews (2024)
44. Is Dairy Foods Restriction Mandatory for Inflammatory Bowel Disease Patients: A Multinational Cross-Sectional Study; [Restricao De Alimentos Lacteos E Obrigatoria Para Pacientes Com Doenca Inflamatoria Intestinal? Estudo Transversal Multinacio-Nal. Arq Gastroenterol.], Arquivos de Gastroenterologia (2022)
45. A Systematic Review and Meta-Analysis of Prospective Studies on Obesity and Risk of Inflammatory Bowel Disease, Nutrition Reviews (2022)
46. The Role of Dietary Inflammation in the Risk of Osteoporosis in Iranian Postmenopausal Women: A Case-Control Study, Scientific Reports (2025)
47. The Mind (Mediterranean-Dash Diet Intervention for Neurodegenerative Delay) and Mediterranean Diets Are Differently Associated With Psychosomatic Complaints Profile in Adults: Results From Sepahan Cross-Sectional Study, Mediterranean Journal of Nutrition and Metabolism (2020)
48. Associations Between Dietary Inflammatory Index and Incidence of Breast and Prostate Cancer: A Systematic Review and Meta-Analysis, Nutrition (2018)
49. The Association of Whole and Refined Grains Consumption With Psychological Disorders Among Iranian Adults, European Journal of Nutrition (2019)
50. Dietary Inflammatory Index and Dietary Energy Density Are Associated With Menopausal Symptoms in Postmenopausal Women: A Cross-Sectional Study, Menopause (2020)