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An Investigation Into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review Publisher Pubmed



Hamedani SG1 ; Pourmasoumi M2 ; Askari G3, 4 ; Bagherniya M3, 4 ; Sathyapalan T5 ; Sahebkar A6, 7
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Gastrointestinal & Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
  3. 3. Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom
  6. 6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Current medicinal chemistry Published:2024


Abstract

Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed in the neurons of the central and peripheral nervous system. However, moderate levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors have been increasingly studied over the last decade due to their neuroprotective role in neurological disorders and hypoxia. Studies have shown that a number of chemicals, pharmaceuticals, and herbal compounds can modulate the expression of Ngb at different dose levels, indicating a protective role against neurodegenerative diseases. Iron chelators, hormones, antidiabetic drugs, anticoagulants, antidepressants, plant derivatives and short-chain fatty acids are among these compounds. Therefore, this study aimed to review the literature focused on the possible effects and mechanisms of chemical, pharmaceutical, and herbal compounds on Ngbs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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