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Neuroprotective Effects of Glycosides Publisher



Ebrahimi MS1, 2 ; Hosseini Z3 ; Khatami A4 ; Abbasikolli M5 ; Sadri Nahand J4 ; Kouchaki E6 ; Mirzaei H7
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Authors Affiliations
  1. 1. Student Research Committee, Kashan University of Medical Sciences, Isfahan, Kashan, Iran
  2. 2. School of Medicine, Kashan University of Medical Sciences, Isfahan, Kashan, Iran
  3. 3. Faculty of Health Science, Ontario Tech University, Oshawa, ON, Canada
  4. 4. Department of Virology, School of Medicine, Tabriz University of Medical Sciences, East Azerbaijan, Tabriz, Iran
  5. 5. Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Neurology, School of Medicine, Physiology Research Center, Kashan University of Medical Sciences, Isfahan, Kashan, Iran
  7. 7. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Isfahan, Kashan, Iran

Source: Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects Published:2023


Abstract

Advantaged from the remarkable penetrative ability into blood–brain barrier, glycosides regulate several signaling pathways in brain cells resulting in suppressed neurotoxins-associated apoptosis, enhanced differentiation and survival and other neuroprotective effects. Beside antiinflammatory and functional benefits of glycoside compounds, the dietary form of glycosides have successfully led to inhibitory effects on senile neurodegeneration and cognitive impairment, if consumed on a regular basis throughout the life. Therefore, glycosides may further meet pharmaceutical features needed for developing a noble brain-protective drug designed for improving brain activity and hindering neurodegenerative diseases. © 2023 Elsevier Inc. All rights reserved.
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