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How Gallic Acid Regulates Molecular Signaling: Role in Cancer Drug Resistance Publisher Pubmed



Hassani S1 ; Ghanbari F2 ; Lotfi M3, 7 ; Alam W4 ; Aschner M5 ; Popovicdjordjevic J6 ; Shahcheraghi SH7, 8, 9 ; Khan H4
Authors
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Authors Affiliations
  1. 1. Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
  2. 2. Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Abortion Research Center, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  4. 4. Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan
  5. 5. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States
  6. 6. Faculty of Agriculture, Department for Chemistry and Biochemistry, University of Belgrade, Nemanjina 6, Belgrade, 11080, Serbia
  7. 7. Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  8. 8. Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  9. 9. Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Medical Oncology Published:2023


Abstract

Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop drug resistance, which can lead to treatment failure or recurrence. Accordingly, anticancer compounds are essential for chemotherapy-resistant cancer cells. Phenolic compounds are of interest in the development of cancer drugs due to their medicinal properties and ability to target different molecular pathways. Gallic acid (GA), as one of the main components of phenol, which is abundantly present in plant compounds such as walnut, sumac, grapes, tea leaves, oak bark, and other plant compounds, has antitumor properties. GA can prevent cancer progression, cell invasion, and metastasis by targeting molecular pathways and is an effective complement to chemotherapy drugs and combating multidrug resistance (MDR). In this review, we discuss various mechanisms related to cancer, the therapeutic potential of GA, the antitumor properties of GA in various cancers, and the targeted delivery of GA with nanocarriers. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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