Whole Spinal Transverse Myelitis in Neuromyelitis Optica Spectrum Disorder Publisher Pubmed

Summary: Rare whole spinal transverse myelitis in NMOSD linked to worse outcomes, often with AQP4 antibodies, needs further study. #NMOSD #Neurology

Etemadifar M¹ ; Mousavi S² ; Salari M³ ; Hosseinian SA⁴ ; Mansouri AR²
Source: Multiple Sclerosis and Related Disorders Published:2024

Abstract

Background: Spinal cord is one of the prominent targets of autoimmune mechanisms in Neuromyelitis Optica Spectrum Disorder (NMOSD). Rarely, NMOSD causes damage to the entire length of the spinal cord, from cervical segments to conus medullaris, which has not been characterized in the existing literature. Material and method: We reviewed medical records, demographic information, and magnetic resonance imaging (MRI) sequences of 174 NMOSD patients from January 2011 to January 2023 who were admitted to Isfahan Multiple Sclerosis center to find patients with whole spinal transverse myelitis (TM). Results: Whole spinal TM was present in five patients (2.9 %). Three patients were seropositive for Aquaporin-4 (AQP4) antibody; Myelin Oligodendrocyte Glycoprotein antibody (MOG IgG) tested negative for all of them. Lower limb weakness was the most frequent clinical complaint. Two patients presented with optic neuritis; One patient reported having episodes of nausea and vomiting. These patients, overall, yielded a higher expanded disability status scale (EDSS) score than the other NMOSD patients. Conclusion: Whole spinal TM is a rare finding in NMOSD, which is strongly associated with a higher severity and a worse outcome of the disease. The role of anti-AQP4 antibodies in the extent of myelitis in NMOSD has yet to be investigated. © 2024 Elsevier B.V.