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Antibacterial, Antibiofilm, Antiswarming, and Antioxidant Activities of Flavonoids Isolated From Allium Colchicifolium Leaves Publisher



Majnooni MB1, 2 ; Ghanadian SM3 ; Mojarrab M2 ; Bahrami G2, 4 ; Mansouri K4 ; Mirzaei A5 ; Farzaei MH2
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Department of Bacteriology and Virology, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran

Source: Journal of Food Biochemistry Published:2023


Abstract

Allium (A.) species are one of the most widespread plants in the world, which have played a special role in terms of nutrition, treatment, and economy since long ago. This study is the first report on the phytochemical and biological activities of A. colchicifolium. Five flavonoids, including isorhamnetin (compound 1), quercetin (compound 2), morin (compound 3), isorhamnetin-3-O-glucoside (compound 4), and quercetin 3-O-glucoside (compound 5), were isolated and purified for the first time from A. colchicifolium leaves. All isolated flavonoids showed antibacterial and antibiofilm activities. Compound 3 revealed prominent antibacterial activities against Staphylococcus (S.) aureus and Proteus (P.) mirabilis. Also, compounds 3 and 5 showed the highest antibiofilm activities on S. aureus and P. mirabilis, respectively. The docking study results showed that compounds 3, 4, and 5 had the most robust interactions with two critical proteins in biofilm formation, including staphylococcal accessory regulator A (SarA) and mannose-resistant Proteus-like fimbriae H (MrpH). Besides, compounds 2 and 3 revealed significant antioxidant activities in 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and ferric (Fe3+)-reducing antioxidant power (FRAP) tests compared to the other compounds and positive controls. Also, the ADMET (absorption, distribution, metabolism, excretion, and toxicity) prediction assay showed that compounds 1, 2, and 3 have suitable physicochemical and pharmacokinetic properties. The results of this study confirm that the flavonoids isolated from the leaves of A. colchicifolium can be promising candidates for use in the pharmaceutical and food industries. © 2023 Mohammad Bagher Majnooni et al.
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