3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss

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3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss Publisher

Zolfaghari B¹ ; Sadeghi M¹ ; Troiano R² ; Lanzotti V²

Source: Phytochemistry Letters Published:2015

Abstract

Abstract Two new sapogenins, named seco-umbilicagenins A and B (1 and 2), possessing a new chemical structure based on a 3,4-seco-spirostane skeleton, were isolated from Allium umbilicatum Boiss. The chemical structures of seco-umbilicagenins A and B were established through a combination of extensive spectroscopic analysis, mainly nuclear magnetic resonance spectroscopy and mass spectrometry, and chemical methods as (2S,25R)-2,5α,6β-trihydroxy-3,4-seco-spirosta-3,4-dioic acid (1) and (2S,25R)-2,4,5α-trihydroxy-6-oxo-3,4-seco-spirostan-3-oic acid (2). Interestingly, the isolated compounds exhibited cytotoxic activity on J-774, murine monocyte/macrophage, and WEHI-164, murine fibrosarcoma, cell lines. To the best of our knowledge this is the first time that 3,4-seco-spirostane sapogenins are isolated from natural sources, being this skeleton obtained by synthetic modification of intact sapogenins. © 2015 Phytochemical Society of Europe.

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Style	Citing Format
MLA	Zolfaghari B, et al.. "3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss." Phytochemistry Letters, vol. 12, no. , 2015, pp. 291-295.
APA	Zolfaghari B, Sadeghi M, Troiano R, Lanzotti V (2015). 3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss. Phytochemistry Letters, 12(), 291-295.
Chicago	Zolfaghari B, Sadeghi M, Troiano R, Lanzotti V. "3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss." Phytochemistry Letters 12, no. (2015): 291-295.
Harvard	Zolfaghari B et al. (2015) '3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss', Phytochemistry Letters, 12(), pp. 291-295.
Vancouver	Zolfaghari B, Sadeghi M, Troiano R, Lanzotti V. 3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss. Phytochemistry Letters. 2015;12():291-295.
BibTex	@article{ author = {Zolfaghari B and Sadeghi M and Troiano R and Lanzotti V}, title = {3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss}, journal = {Phytochemistry Letters}, volume = {12}, number = {}, pages = {291-295}, year = {2015} }
RIS	TY - JOUR AU - Zolfaghari B AU - Sadeghi M AU - Troiano R AU - Lanzotti V TI - 3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss JO - Phytochemistry Letters VL - 12 IS - SP - 291 EP - 295 PY - 2015 ER -

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