3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss

3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss Publisher

Zolfaghari B¹ ; Sadeghi M¹ ; Troiano R² ; Lanzotti V²

Show Affiliations

1. Department of Pharmacognosy, Isfahan University of Medical Sciences, Hezar Jerib Avenue, Isfahan, 73461, Iran
2. Dipartimento di Agraria, Universita di Napoli Federico II, Via Universita 100, Portici, Naples, 80055, Italy

Source: Phytochemistry Letters Published:2015

Abstract

Abstract Two new sapogenins, named seco-umbilicagenins A and B (1 and 2), possessing a new chemical structure based on a 3,4-seco-spirostane skeleton, were isolated from Allium umbilicatum Boiss. The chemical structures of seco-umbilicagenins A and B were established through a combination of extensive spectroscopic analysis, mainly nuclear magnetic resonance spectroscopy and mass spectrometry, and chemical methods as (2S,25R)-2,5α,6β-trihydroxy-3,4-seco-spirosta-3,4-dioic acid (1) and (2S,25R)-2,4,5α-trihydroxy-6-oxo-3,4-seco-spirostan-3-oic acid (2). Interestingly, the isolated compounds exhibited cytotoxic activity on J-774, murine monocyte/macrophage, and WEHI-164, murine fibrosarcoma, cell lines. To the best of our knowledge this is the first time that 3,4-seco-spirostane sapogenins are isolated from natural sources, being this skeleton obtained by synthetic modification of intact sapogenins. © 2015 Phytochemical Society of Europe.

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Behzad Zolfaghari (12)

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Style	Citing Format
MLA	Zolfaghari B, et al.. "3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss." Phytochemistry Letters, vol. 12, no. , 2015, pp. 291-295.
APA	Zolfaghari B, Sadeghi M, Troiano R, Lanzotti V (2015). 3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss. Phytochemistry Letters, 12(), 291-295.
Chicago	Zolfaghari B, Sadeghi M, Troiano R, Lanzotti V. "3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss." Phytochemistry Letters 12, no. (2015): 291-295.
Harvard	Zolfaghari B et al. (2015) '3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss', Phytochemistry Letters, 12(), pp. 291-295.
Vancouver	Zolfaghari B, Sadeghi M, Troiano R, Lanzotti V. 3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss. Phytochemistry Letters. 2015;12():291-295.
BibTex	@article{ author = {Zolfaghari B and Sadeghi M and Troiano R and Lanzotti V}, title = {3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss}, journal = {Phytochemistry Letters}, volume = {12}, number = {}, pages = {291-295}, year = {2015} }
RIS	TY - JOUR AU - Zolfaghari B AU - Sadeghi M AU - Troiano R AU - Lanzotti V TI - 3,4-Seco-Spirostane Sapogenins With Cytotoxic Activity From Allium Umbilicatum Boiss JO - Phytochemistry Letters VL - 12 IS - SP - 291 EP - 295 PY - 2015 ER -

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