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Association of Helicobacter Pylori Infection With Severity of Coronary Heart Disease



Rogha M1 ; Dadkhah D1 ; Pourmoghaddas Z2 ; Shirneshan K3 ; Nikvarz M1 ; Pourmoghaddas M4
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran
  2. 2. Young Researchers Club, Najafabad Branch, Islamic Azad University, Isfahan, Iran
  3. 3. Isfahan Shariati Hospital, Isfahan, Iran
  4. 4. Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: ARYA Atherosclerosis Published:2012

Abstract

BACKGROUND: There are few literatures evaluating the association between cytotoxinassociated gene A (CagA) positive strains of Helicobacter pylori (HP) and the severity of coronary heart disease (CHD). This study was designed to investigate this association. METHODS: Medical and drug history of 112 consecutive patients who were candidate for coronary angiography were taken. Fasting blood samples were obtained to measure C-reactive protein (CRP), anti Helicobacter pylori immunoglobulin G (anti-HP IgG), anti-CagA antibody (Ab) and interlukine-6 (IL6). According to angiography reports, participants were divided into patients with mild (n = 69) and with sever CHD (n = 36). To measure the association between CagA positive strains of HP with the severity of CHD, multivariate logistic regression tests were used by adjusting age, sex, history of diabetes mellitus (DM), dyslipidemia (DLP), and/or hypertension (HTN), CRP status and IL-6 level. RESULTS: The analysis was concluded on 105 subjects. HP infection and CagA Ab were not significantly higher compared to the patients with severe and mild CHD (P = 0.28 and P = 0.68, respectively). Colonization of CagA positive HP did not significantly associate with severity of CHD (OR 1.05, 95% CI 0.33-3. 39). CONCLUSION: Colonization of CagA positive HP was not an independent risk factor for severe coronary heart disease.
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