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The Efficacy of Curcumin‑Piperine Supplementation in Patients With Nonproliferative Diabetic Retinopathy: An Optical Coherence Tomography Angiography‑Based Randomized Controlled Trial Publisher



Amini S1 ; Dehghani A2 ; Sahebkar A3, 4, 5 ; Iraj B6 ; Rezaeianramsheh A2 ; Askari G7, 8 ; Majeed M9 ; Bagherniya M7, 8
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, Student Research Committee, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Sabinsa Corporation, East Windsor, NJ, United States

Source: Journal of Research in Medical Sciences Published:2024


Abstract

Background: Diabetic retinopathy (DR) is one of the complications of diabetes. This study was conducted to investigate the effect of curcumin‑piperine on laboratory factors and macular vascular in DR. Materials and Methods: The present study was a randomized, placebo‑controlled, double‑blind, parallel‑arm clinical trial that was conducted on 60 patients with DR aged 30–65 years. Patients were randomized into two groups to receive (i) 1010 mg/day of curcumin‑piperine (two tablets per day, each tablet containing 500 mg curcuminoids and 5 mg piperine) (n = 30) or (ii) the matched placebo (n = 30) for 12 weeks. The investigated factors included optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), oxidative stress factors, C‑reactive protein (CRP), fasting blood glucose (FBG), triglycerides (TGs), blood urea nitrogen (BUN), and creatinine. Results: The trial was completed by 27 patients in the intervention group and 29 patients in the placebo group. Curcumin‑piperine significantly increased total antioxidant capacity (0.86 ± 0.66 vs. 0.45 ± 0.89; P = 0.022) and superoxide dismutases (0.77 ± 2.11 vs. −0.45 ± 3.08; P = 0.031), while it decreased and malondialdehyde (MDA) (−1.06 ± 5.80 vs. 1.89 ± 6.12; P = 0.043) and creatinine (−0.04 ± 0.16 vs. 0.03 ± 0.05; P = 0.042) compared with placebo. However, this supplement had no significant effect on CRP, FBG, TG, BUN, OCT, and OCTA. There were no adverse reactions. Conclusion: Curcumin‑piperine is effective in improving oxidative stress and reducing creatinine in DR. Further trials are necessary to confirm these promising findings. © 2024 Journal of Research in Medical Sciences.
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