Sesquiterpenes and Flavonoids of Anthemis Odontostephana Var. Odontostephana Publisher



Shokoohinia Y^{1, 2} ; Sajjadi SE³ ; Jassbi AR⁴ ; Moradi H⁵ ; Ghassemi N³ ; Schneider B⁶ Show Affiliations
Source: Chemistry of Natural Compounds Published:2015

Abstract

Phytochemical investigation of the flowers of Anthemis odontostephana Boiss. var. odontostephana (Asteraceae) resulted in the isolation of a natural cyclohexenone sesquiterpenoid with a bisabolene skeleton, 1-hydroxydelobanone (1), for the first time as a natural product, and a previously reported cyclohexenone derivative, antheminone A (2), along with two known flavonoids, pectolinaringenin (3), and salvigenin (4). The stereochemistry at positions C-4 and C-5 of the cyclohexenone ring of compound 2 was established based on 1H-1H spin-spin coupling constants and ROESY spectra. Compounds 2 and 3 were reported previously as antileishmanial and cytotoxic agents by other authors. The structures of the compounds were elucidated using NMR spectroscopic methods including 1H NMR, 13C NMR, APT, COSY, HSQC, and HMBC, and mass spectrometry. © 2015 Springer Science+Business Media New York.