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6(17)-Epoxylathyrane Diterpenes From Euphorbia Sogdiana Popov With Cytotoxic Activity Publisher Pubmed



Yazdiniapour Z1 ; Ghanadian M1 ; Zolfaghari B1 ; Lanzotti V2
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Dipartimento di Agraria, Universita di Napoli Federico II, Portici, Napoli, Italy

Source: Fitoterapia Published:2016


Abstract

Phytochemical analysis of Euphorbia sogdiana Popov, Euphorbiaceae, afforded the isolation of three new diterpenes based on the rare 6(17)-epoxylathyrane skeleton (1-3), along with a lathyrane (4), a myrsinane (5) and a tigliane (6) diterpenoids, previously isolated from Euphorbia aellenii. Their chemical structures were established through a combination of nuclear magnetic resonance spectroscopy and mass spectrometric methods. The epoxylathyranes 1-4 were tested to evaluate their cytotoxic activity against Jurkat T-leukemia and EJ-138 bladder cancer cells and their chemical analogy allowed to propose some structure activity relationships. © 2015 Published by Elsevier B.V.
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