Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Does Fenugreek (Trigonella Foenum-Graecum) Seed Improve Inflammation, and Oxidative Stress in Patients With Type 2 Diabetes Mellitus? a Parallel Group Randomized Clinical Trial Publisher



Tavakoly R1 ; Maracy MR2 ; Karimifar M3 ; Entezari MH1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition & Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Epidemiology & Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: European Journal of Integrative Medicine Published:2018


Abstract

Introduction: Fenugreek seed has not previously been investigated for its effect on oxidative stress and inflammation in human subjects. The aim of this study was to examine the effects of fenugreek seeds on selected inflammation and oxidative stress biomarkers in patients with type 2 diabetes mellitus (T2DM). Methods: Forty-eight T2DM patients were randomly assigned to either an intervention or control group using a parallel group design. The intervention group received 15 g/day fenugreek seed powder. There was no placebo used in this study due to intervention food-based nature. Dietary intake and physical activity were assessed during the study. Blood samples were collected at the baseline and after 8 wk of the intervention to quantify intended variables. Results: Fenugreek seed consumption resulted in a significant decrease in high-sensitivity C-reactive protein (hs-CRP) (p = 0.012) compared to the control group. Within-group analysis showed a significant increase in superoxide dismutase (SOD) activity (p = 0.001) among the fenugreek group without any changes in the control group. There was no significant effect of fenugreek seed on glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), serum interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Conclusion: The present study indicates some promising properties for fenugreek seed on biomarkers of inflammation and oxidative stress in T2DM patients, but further human researches are needed. This trial was registered at www.irct.ir as IRCT2017021232294N2. © 2018 Elsevier GmbH
Related Docs
View other Related Docs
1. The Effect of Fenugreek Seed Supplementation on Serum Irisin Levels, Blood Pressure, and Liver and Kidney Function in Patients With Type 2 Diabetes Mellitus: A Parallel Randomized Clinical Trial, Complementary Therapies in Medicine (2020)
2. Therapeutic Effect of Fenugreek Supplementation on Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Clinical Trials, Heliyon (2024)
3. Effect of Fenugreek Seeds on Blood Glucose and Lipid Profiles in Type 2 Diabetic Patients, International Journal for Vitamin and Nutrition Research (2009)
4. The Effect of Purslane Seeds on Biomarkers of Oxidative Stress in Diabetic Patients: A Randomized Controlled Cross-Over Clinical Trial, International Journal of Preventive Medicine (2015)
5. Effect of Bread Fortification With Pomegranate Peel Powder on Glycemic Indicators, Antioxidant Status, Inflammation and Mood in Patients With Type 2 Diabetes: Study Protocol for a Randomized, Triple-Blind, and Placebo-Controlled Trial, Journal of Diabetes and Metabolic Disorders (2023)
6. Effect of Fenugreek Consumption on Serum Lipid Profile: A Systematic Review and Meta-Analysis, Phytotherapy Research (2020)
7. Effects of Fenugreek Seeds on Adipogenesis and Lipolysis in Normal and Diabetic Rats, Pakistan Journal of Biological Sciences (2014)
8. Effects of Pomegranate Seed Oil on Metabolic State of Patients With Type 2 Diabetes Mellitus, International Journal of Preventive Medicine (2016)
Experts (# of related papers)
View all Related Experts
Gholamreza Askari (16)
Awat Feizi (14)
Other Related Docs
9. Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes Patients, The review of diabetic studies : RDS (2014)
10. The Effects of Wheat Germ Supplementation on Metabolic Profile in Patients With Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial, Phytotherapy Research (2020)
11. Antioxidant Effects of Astaxanthin and Metformin Combined Therapy in Type 2 Diabetes Mellitus Patients: A Randomized Double-Blind Controlled Clinical Trial, Research in Pharmaceutical Sciences (2022)
12. The Effects of Oral Trehalose on Glycaemia, Inflammation, and Quality of Life in Patients With Type 2 Diabetes: A Pilot Randomized Controlled Trial, Archives of Medical Science (2023)
13. The Effects of Silymarin Consumption on Inflammation and Oxidative Stress in Adults: A Systematic Review and Meta-Analysis, Inflammopharmacology (2024)
14. Effects of Berberis Vulgaris Fruit Extract on Oxidative Stress Status in the Kidney and Liver of Diabetic Rats, Journal of Complementary and Integrative Medicine (2024)
15. The Effects of Berberis Integerrima Fruit Extract on Glycemic Control Parameters in Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial, Evidence-based Complementary and Alternative Medicine (2021)
16. The Effect of Cocoa Consumption on Markers of Oxidative Stress: A Systematic Review and Meta-Analysis of Interventional Studies, Complementary Therapies in Medicine (2020)
17. Clinical Trial of the Effects of Coenzyme Q10 Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Hemodialysis Patients, International Journal of Preventive Medicine (2019)
18. Assessment and Comparison of the Antioxidant Defense System in Patients With Type 2 Diabetes, Diabetic Nephropathy and Healthy People: A Case–Control Study, Clinical Nutrition ESPEN (2020)
19. Evaluation of the Effects of Roselle (Hibiscus Sabdariffa L.) on Oxidative Stress and Serum Levels of Lipids, Insulin and Hs-Crp in Adult Patients With Metabolic Syndrome: A Double-Blind Placebo-Controlled Clinical Trial, Journal of Complementary and Integrative Medicine (2016)
20. The Impact of Probiotic Soy Milk Consumption on Oxidative Stress Among Type 2 Diabetic Kidney Disease Patients: A Randomized Controlled Clinical Trial, Journal of Renal Nutrition (2017)
21. Effects of Daily Consumption of Cashews on Oxidative Stress and Atherogenic Indices in Patients With Type 2 Diabetes: A Randomized, Controlled-Feeding Trial, International Journal of Endocrinology and Metabolism (2019)
22. The Effects of Astaxanthin on Ampk/Autophagy Axis and Inflammation in Type 2 Diabetes Patients: A Randomized, Double-Blind, Placebo-Controlled Trial, Gene Reports (2023)
23. Antioxidant Effect of Turmeric and Saffron on the Oxidation of Hepatocytes, Ldl and Non-Enzymatic Glycation of Hemoglobin, Journal of Medicinal Plants (2005)
24. Protective Effect of Quercetin on Alteration of Antioxidant Genes Expression and Histological Changes in the Dental Pulp of the Streptozotocin-Diabetic Rats, Archives of Oral Biology (2021)
25. Acute and Long Term Effects of Grape and Pomegranate Juice Consumption on Endothelial Dysfunction in Pediatric Metabolic Syndrome, Journal of Research in Medical Sciences (2011)
26. Is Consumption of Pomegranate Supplementation Effective on Oxidative Stress Biomarkers Including Mda, Ox-Ldl, Pox 1, Gpx, Tac, and Tbras? a Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Problems in Cardiology (2023)
27. A Personalised Diet Study: The Interaction Between Apoa2 −265T > C Polymorphism and Dietary Inflammatory Index on Oxidative and Inflammatory Markers and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study, International Journal of Clinical Practice (2021)
28. Effect of Sesame Supplementation on Body Composition and Lipid Profile in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2024)
29. Effects of Dietary Whole Grain, Fruit, and Vegetables on Weight and Inflammatory Biomarkers in Overweight and Obese Women, Eating and Weight Disorders (2020)
30. New Concepts in Nutraceuticals As Alternative for Pharmaceuticals, International Journal of Preventive Medicine (2014)
31. Astaxanthin Improves Fatty Acid Dysregulation in Diabetes by Controlling the Ampk-Sirt1 Pathway, EXCLI Journal (2023)
32. Effects of Vitamin D Supplementation on 8-Hydroxydeoxy Guanosine and 3-Nitrotyrosine in Patients With Type 2 Diabetes: A Randomized Clinical Trial, Progress in Nutrition (2019)
33. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Evaluating the Garlic Supplement Effects on Some Serum Biomarkers of Oxidative Stress, and Quality of Life in Women With Rheumatoid Arthritis, International Journal of Clinical Practice (2020)
34. Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Drug Targets (2023)
35. Effect of Non-Soy Legume Consumption on Inflammation and Serum Adiponectin Levels Among First-Degree Relatives of Patients With Diabetes: A Randomized, Crossover Study, Nutrition (2015)
36. The Effect of Quercetin Supplementation on Selected Markers of Inflammation and Oxidative Stress, Journal of Research in Medical Sciences (2012)
37. Can Flaxseed Supplementation Affect Circulating Adipokines in Adults? an Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, Frontiers in Nutrition (2023)
38. The Effect of Conjugated Linoleic Acid Supplementation on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Nutrition ESPEN (2022)
39. The Protective Effects of Ziziphus Vulgaris L. Fruits on Biochemical and Histological Abnormalities Induced by Diabetes in Rats, Journal of Complementary and Integrative Medicine (2014)
40. The Inhibitory Effects of Pure Flavonoids on in Vitro Protein Glycosylation, Journal of Herbal Pharmacotherapy (2002)
41. Systematic Review and Meta-Analysis of Oxidative Stress and Antioxidant Markers in Recurrent Aphthous Stomatitis, BMC Oral Health (2023)
42. Effects of Probiotic Supplementation in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis, Nutrition Reviews (2016)
43. The Effect of Rosa Damascena Extract on Blood Glucose and Insulin Levels in Diabetic Rats, Journal of Isfahan Medical School (2020)
44. Oxidant/Antioxidant Status in Type-2 Diabetes Mellitus Patients With Metabolic Syndrome, Journal of Research in Medical Sciences (2021)
45. Cinnamon Supplementation Improves Blood Pressure in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Diabetology (2020)
46. Nigella Sativa in Controlling Type 2 Diabetes, Cardiovascular, and Rheumatoid Arthritis Diseases: Molecular Aspects, Journal of Research in Medical Sciences (2021)
47. The Effect of Pomegranate (Punica Granatum) Supplementation on Metabolic Status in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis, Complementary Therapies in Medicine (2020)
48. Salsalate Efficacy in Blood Glucose Level Reduction in Diabetes, Journal of Isfahan Medical School (2009)
49. Effects of Resvin Supplement on the Levels of Interleukin-6 and C-Reactive Protein and Insulin Resistance in Women With Type 2 Diabetes, Journal of Isfahan Medical School (2015)
50. Ultra-Processed Food Consumption and Adult Diabetes Risk: A Systematic Review and Dose-Response Meta-Analysis, Nutrients (2021)