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Circular Rnas: Pivotal Role in the Leukemogenesis and Novel Indicators for the Diagnosis and Prognosis of Acute Myeloid Leukemia Publisher



Rahmati A1, 2 ; Mafi A3 ; Soleymani F4 ; Babaei Aghdam Z5 ; Masihipour N6 ; Ghezelbash B7 ; Asemi R8 ; Aschner M9 ; Vakili O3 ; Homayoonfal M10 ; Asemi Z10 ; Sharifi M8 ; Azadi A11 ; Mirzaei H10 Show All Authors
Authors
  1. Rahmati A1, 2
  2. Mafi A3
  3. Soleymani F4
  4. Babaei Aghdam Z5
  5. Masihipour N6
  6. Ghezelbash B7
  7. Asemi R8
  8. Aschner M9
  9. Vakili O3
  10. Homayoonfal M10
  11. Asemi Z10
  12. Sharifi M8
  13. Azadi A11
  14. Mirzaei H10
  15. Aghadavod E10, 12
Show Affiliations
Authors Affiliations
  1. 1. Department of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Basic Sciences, Faculty of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran
  3. 3. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Imaging Sciences Research Group, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Medicine, Lorestan University of Medical Science, Lorestan, Iran
  7. 7. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States
  10. 10. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  11. 11. Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  12. 12. Department of Clinical Biochemistry, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

Source: Frontiers in Oncology Published:2023


Abstract

Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of non-coding RNAs (ncRNAs) with a unique loop structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been identified exhibiting either up-regulation or down-regulation in AML patients compared with healthy controls. Recent studies have reported that circRNAs regulate leukemia cell proliferation, stemness, and apoptosis, both positively and negatively. Additionally, circRNAs could be promising biomarkers and therapeutic targets in AML. In this study, we present a comprehensive review of the regulatory roles and potentials of a number of dysregulated circRNAs in AML. Copyright © 2023 Rahmati, Mafi, Soleymani, Babaei Aghdam, Masihipour, Ghezelbash, Asemi, Aschner, Vakili, Homayoonfal, Asemi, Sharifi, Azadi, Mirzaei and Aghadavod.
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