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The Role of Cobalamin in Multiple Sclerosis: An Update Publisher



Golabi M1 ; Kazemi D2 ; Chadeganipour AS3 ; Fouladseresht H1 ; Sullman MJM5, 6 ; Ghezelbash B4 ; Dastgerdi AY7 ; Eskandari N1
Authors
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Authors Affiliations
  1. 1. Applied Physiology Research Center, Cardiovascular Research Institute, Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Student Research Committee, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Laboratory Hematology and Blood Banking, School of Allied Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus
  6. 6. Department of Social Sciences, University of Nicosia, Nicosia, Cyprus
  7. 7. Department of Cell and Molecular Biology, Falavarjan Branch, Islamic Azad University of Science, Isfahan, Iran

Source: Inflammation Published:2024


Abstract

Multiple sclerosis (MS) is a neurodegenerative condition that results in axonal and permanent damage to the central nervous system, necessitating healing owing to autoimmune reactions and persistent neuroinflammation. Antioxidant and anti-inflammatory drugs are essential for the management of oxidative stress and neuroinflammation. Additionally, multivitamin supplementation, particularly vitamin B12 (cobalamin), may be beneficial for neuronal protection. Although there is no documented connection between vitamin B12 deficiency and MS, researchers have explored its potential as a metabolic cause. This review highlights the therapeutic benefits of cobalamin (Cbl) in patients with MS. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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