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Genetic Association With Low Concentrations of High Density Lipoprotein-Cholesterol in a Pediatric Population of the Middle East and North Africa: The Caspian-Iii Study Publisher Pubmed



Kelishadi R1 ; Haghjooy Javanmard S2 ; Tajadini MH2 ; Mansourian M1, 2, 3 ; Motlagh ME4 ; Ardalan G1 ; Ban M5
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Authors Affiliations
  1. 1. Pediatrics Department, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Physiology Department, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biostatistics Department, Faculty of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Pediatrics Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, University of Western Ontario, Ontario, Canada

Source: Atherosclerosis Published:2014


Abstract

Objective: Depressed high-density lipoprotein cholesterol (HDL-C) is prevalent the Middle East and North Africa. Some studies have documented associations between HDL-C and several single nucleotide polymorphisms (SNPs) in candidate gene polymorphisms. Methods: We investigated the associations between SNP genotypes and HDL-C levels in Iranian students, aged 10-18 years. Genotyping was performed in 750 randomly selected participants among those with low HDL-C levels (below 5th percentile), intermediate HDL-C levels (5-95th) and high HDL-C levels (above the 95th percentile). Minor allele frequencies (MAFs) of the SNPs of interest were compared between the three HDL-C groups. Results: The vast majority of pairwise comparisons of MAFs between HDL-C groups were significant. Pairwise comparisons between low and high HDL-C groups showed significant between-group differences in MAFs for all SNPs, except for APOC3 rs5128. Pairwise comparisons between low and intermediate HDL-C groups showed significant between-group differences in MAFs for all SNPs, except for APOC3 rs5128 and APOA1 rs2893157. Pairwise comparisons between intermediate and high HDL-C groups showed significant between-group differences in MAFs for all SNPs, except for ABCA1 APOC3 rs5128 and APOA1 rs2893157. After adjustment for confounding factors, including age, sex, body mass index, low physical activity, consumption of saturated fats, and socioeconomic status, ABCA1 r1587K and CETP A373P significantly increased the risk of depressed HDL-C, and CETP Taq1 had a protective role. Conclusion: This study replicated several associations between HDL-C levels and candidate gene SNPs from genome-wide associations with HDL-C in Iranians from the pediatric age group. © 2014 Elsevier Ireland Ltd.
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