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Advances in Bioengineered Car T/Nk Cell Therapy for Glioblastoma: Overcoming Immunosuppression and Nanotechnology-Based Strategies for Enhanced Car T/Nk Cell Therapy Publisher



Dana N1 ; Dabiri A1 ; Najafi MB1 ; Rahimi A1 ; Ishaghi SMM2 ; Shariati L3, 4 ; Shao M5 ; Borzacchiello A6 ; Rahimmanesh I1 ; Makvandi P7, 8, 9
Authors
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Authors Affiliations
  1. 1. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Microbiology, Faculty of biological science and technology, The University of Isfahan, Isfahan, Iran
  3. 3. Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Biosensor Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Otorhinolaryngology, The Dingli Clinical College affiliated to Wenzhou Medical University, Wenzhou Central Hospital, Wenzhou, 325000, China
  6. 6. Institute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Naples, Italy
  7. 7. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Zhejiang, China
  8. 8. Centre of Research Impact and Outreach, Chitkara University, Punjab, Rajpura, 140417, India
  9. 9. University Centre for Research & Development, Chandigarh University, Punjab, Mohali, India

Source: Bioengineering and Translational Medicine Published:2024


Abstract

Glioblastoma is a strong challenge in the worldwide field of central nervous system malignancies. GBM's inherent heterogeneity, along with the formation of an immunosuppressive tumor microenvironment, supports its resistance to current therapy methods. Immunotherapeutic methods have emerged as potential options in recent years. However, because of the inherent limits of traditional immunotherapeutic techniques innovative approaches are required. Advances in cut-edge techniques provide a possible route for improving effector cell effectiveness. This review gives insight into the complicated immunosuppressive pathways in GBM, with a particular emphasis on CAR T/NK-cell treatment as a potential achievement. Recognizing and addressing these concerns might open the way for more effective and focused glioblastoma therapies, providing hope for the future with the aim of improved outcomes for patients. In addition, this review presents valuable insights into the integration of nanotechnology into CAR T/NK cell therapy for enhanced efficiency of these personalized gene therapy products. © 2024 The Author(s). Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.
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