Anti Candidal Activity of Echinophora Platyloba Against Candida Albicans and Comparison With Amphotricin



Mahboubi M¹ ; Avijgan M² ; Darabi M¹ ; Kasaiyan N²
Source: Journal of Medicinal Plants Published:2009

Abstract

Background & Aim: Increasing usage of medical plants for medical treatment made for this branch of complementary medicine a unique place. Methods: This study evaluated the anti candidal activity of Echinophora platyloba extracts and amphotricin B against Candida albicans by micro broth dilution assay and Disc diffusion method. The synergism between amphotricin B and ethanolic extract of E. platyloba was assessed by micro broth dilution assay. Amphotricin B was diluted at concentration between 16-0.125 μg ml -1. Each tube contains 0.78 mg ml-1 E. platyloba extract. The MIC and MBC of Amphotricin B was recorded. Results: The MIC and MBC of ethanolic extract of E. platyloba and amphotricin B against C. albicans were 3125, 1560 μg ml-1 and 2, 8 μg ml-1 respectively. The MIC, MBC of amphotricin B decreased to 1, 2 μg ml-1 when 0.78 mg ml-1 of extract was added. Conclusion: Amphotricin B is a potent antifungal agent and MIC and MBC of E. platyloba is 780, 390 times less potent than amphotricin B, but usage the amphotricin B and E. platyloba extract in combination increased the potency of amphotricin B which shows a synergistic effect.