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Effects of Select Dietary Supplements on the Prevention and Treatment of Viral Respiratory Tract Infections: A Systematic Review of Randomized Controlled Trials Publisher Pubmed



Shokrimashhadi N1 ; Kazemi M2 ; Saadat S3 ; Moradi S4, 5
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Division of Nutritional Sciences, Human Metabolic Research Unit, Cornell University, Ithaca, NY, United States
  3. 3. Department of Computer Sciences, Faculty of Mathematics and Natural Sciences, Heinrich Heine Universitat, Dusseldorf, Germany
  4. 4. Halal Research Center of IRI, FDA, Tehran, Iran
  5. 5. Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Expert Review of Respiratory Medicine Published:2021


Abstract

Introduction: Viral respiratory tract infections (RTIs) have been recognized as a global public health burden. Despite current theories about their effectiveness, the true benefits of dietary supplements on the prevention and treatment of viral RTIs remain elusive, due to contradictory reports. Hence, we aimed to evaluate the effectiveness of dietary supplements on the prevention and treatment of viral RTIs. Areas covered: We systematically searched databases of PubMed, Web of Science, Scopus, and Google Scholar through 4 March 2020, to identify randomized controlled trials that evaluated the effects of consuming selected dietary supplements on the prevention or treatment of viral RTIs. Expert opinion: Thirty-nine randomized controlled trials (n = 16,797 participants) were eligible and included. Namely, vitamin D supplementation appeared to improve viral RTIs across cohorts particulate in those with vitamin D deficiency. Among the evaluated dietary supplements, specific lactobacillus strains were used most commonly with selected prebiotics that showed potentially positive effects on the prevention and treatment of viral RTIs. Further, ginseng extract supplementation may effectively prevent viral RTIs as adjuvant therapy. However, longitudinal research is required to confirm these observations and address the optimal dose, duration, and safety of dietary supplements being publicly recommended. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
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