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Regenerative Influence of Nanostructured Bredigite (Ca7mgsi4o16)/Anodic Spark Coating on Biodegradable Az91 Magnesium Alloy Implants for Bone Healing Publisher



Razavi M1, 2, 4 ; Fathi M1, 2 ; Savabi O3 ; Vashaee D5 ; Tayebi L4, 6, 7
Authors
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Authors Affiliations
  1. 1. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  4. 4. School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, 74106, OK, United States
  5. 5. Electrical and Computer Engineering Department, North Carolina State University, Raleigh, 27606, NC, United States
  6. 6. Department of Developmental Sciences, Marquette University, School of Dentistry, Milwaukee, 53233, WI, United States
  7. 7. Biomaterials and Advanced Drug Delivery Laboratory, Stanford University, Palo Alto, CA, United States

Source: Materials Letters Published:2015


Abstract

Magnesium has been recently introduced as a novel biodegradable material for bone healing. However, the fast degradation of this material results in the fast release of hydrogen which limits its clinical applications. In view of that, in the present study, we attempt to overcome this drawback using a bredigite (Ca7MgSi4O16) coating. In our previous work, we have coated AZ91 magnesium implants with bredigite through the combination of anodic spark deposition (ASD) and electrophoretic deposition (EPD) techniques. As continuation to that work, in this paper, we have focused on the in vivo examination of the bredigite/ASD compared to the plain ASD coated and the uncoated AZ91 substrates. The results of the in vivo animal test in the greater trochanter of rabbits indicated improved regeneration of bone and less bone inflammation upon employing bredigite/ASD coated implants. In addition, an enhancement in in vivo biodegradation was observed by the reduction in magnesium ion released in the blood plasma. In summary, a surface treatment using bredigite on magnesium implants promotes their bone healing capabilities for future clinical applications.
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