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Improvement of Biodegradability, Bioactivity, Mechanical Integrity and Cytocompatibility Behavior of Biodegradable Mg Based Orthopedic Implants Using Nanostructured Bredigite (Ca7mgsi4o16) Bioceramic Coated Via Asd/Epd Technique Publisher Pubmed



Razavi M1, 3, 4, 5 ; Fathi M1, 2 ; Savabi O3 ; Vashaee D5 ; Tayebi L4, 6
Authors
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Authors Affiliations
  1. 1. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  2. 2. Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  4. 4. School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, 74106, OK, United States
  5. 5. School of Electrical and Computer Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, 74106, OK, United States
  6. 6. School of Chemical Engineering, Oklahoma State University, Stillwater, 74078, OK, United States

Source: Annals of Biomedical Engineering Published:2014


Abstract

This research explored the influence of surface modification of AZ91 Mg alloy on the biodegradation, bioactivity, mechanical integrity and cytocompatibility of the alloy. For this purpose, a nanostructured bredigite (Ca7MgSi4O16) ceramic coating was prepared on biodegradable AZ91 Mg alloy through anodic spark deposition and electrophoretic deposition method. The phase composition and surface morphology of the coated alloy were characterized by X-ray diffraction, scanning electron microscope and transmission electron microscope. The properties of samples were investigated by electrochemical measurements, immersion test, compression examination and cell culturing. The results showed that the degradation resistance, bioactivity, mechanical integrity and cytocompatibility of biodegradable Mg alloy were improved by the anodic spark deposition and electrophorretic deposition of the nanostructured bredigite coating. Therefore, the nanostructured bredigite ceramic coating is identified as a good coating for AZ91 Mg alloy for the purpose of making biodegradable metallic orthopedic implants. © 2014, Biomedical Engineering Society.
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