Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Ultrasound Therapy in the Presence of Combined Zinc Oxide/Gold Nanocomposite on Melanoma Cell Line Publisher



Esmailzadeh A1 ; Shanei A2 ; Attaran N3 ; Najmoddin N4 ; Shirazi AA4 ; Hejazi SH5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Medical Nanotechnology, Applied Biophotonics Research Center, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Department of Biomedical Engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2023


Abstract

Background: Zinc oxide nanoparticles can produce free radicals due to their piezoelectric properties, which are needed for cancer treatment. Also, using ultrasound waves in combination with zinc oxide nanoparticles can help increase the response to sonodynamic therapy by synergistically producing free radicals. On the other hand, with gold nanoparticles as a place for cavitation in the ultrasound field, the intensity threshold required for cavitation is reduced, reducing the damage to normal cells. This study aimed to investigate the effect of sonodynamic therapy of melanoma with zinc oxide/gold nanocomposite as a sonosensitizer. Methods: Chemical dosimetry was used to determine the level of free radicals produced due to combined zinc oxide/gold nanocomposite with and without ultrasound radiation. Also, measuring the survival and apoptosis rate in the cultured melanoma cells was done in-vitro by MTT and flow cytometry tests, respectively. Findings: With the increase in the production of free radicals, the survival percentage of melanoma cells treated with combined zinc oxide/gold nanocomposite and ultrasound waves at an intensity of 2 W/cm2 showed the most significant decrease (by 20%) which was significantly different from the control group. Also, the apoptosis level caused by sonodynamic therapy with zinc oxide/gold nanocomposite increased significantly. Conclusion: Using ultrasound waves in combination with zinc oxide/gold nanocomposite can play an influential role in improving the response of melanoma to treatment by raising the level of free radicals and reducing the general toxicity for non-cancerous cells by lowering the cavitation threshold. © 2023 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Evaluation of Ultrasound-Mediated Chemotherapy Treatment Using Dacarbazine on B16f10 Melanoma Cell Line, Journal of Isfahan Medical School (2022)
2. Sonodynamic Therapy Using Protoporphyrin Ix Conjugated to Gold Nanoparticles: An in Vivo Study on a Colon Tumor Model, Iranian Journal of Basic Medical Sciences (2012)
3. Monitoring of Transient Cavitation Induced by Ultrasound and Intense Pulsed Light in Presence of Gold Nanoparticles, Ultrasonics Sonochemistry (2014)
4. Cancerous Cell Destruction Using Low Level Ultrasound in the Presence of Gold Nanoparticles: An in Vitro Study on 4T1 Cells, Current Nanoscience (2018)
5. The Role of Gold Nanoparticles in Sonosensitization of Human Cervical Carcinoma Cell Line Under Ultrasound Irradiation: An in Vitro Study, Journal of Nano Research (2019)
6. Bystander Effect of Sonodynamic Therapy in the Presence of Gold Nanoparticles: An In-Vitro Study, International Journal of Radiation Research (2023)
7. The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles, Journal of Isfahan Medical School (2018)
8. Effect of Targeted Gold Nanoparticles Size on Acoustic Cavitation: An in Vitro Study on Melanoma Cells, Ultrasonics (2020)
Experts (# of related papers)
View all Related Experts
Ahmad Shanei (31)
Seyed Hossein Hejazi (11)
Other Related Docs
9. Therapeutic Effects of Acoustic Cavitation in the Presence of Gold Nanoparticles on a Colon Tumor Model, Journal of Ultrasound in Medicine (2013)
10. Synergistic Effect of the Combination of Triethylene-Glycol Modified Fe3o4 Nanoparticles and Ultrasound Wave on Mcf-7 Cells, Journal of Magnetism and Magnetic Materials (2015)
11. The Effect of Ultrasound Waves on Melanoma Cells in Presence of Gold Nanoparticles, Journal of Isfahan Medical School (2017)
12. Evaluation of Acoustic Cavitation in Terephthalic Acid Solutions Containing Gold Nanoparticles by the Spectrofluorometry Method, International Journal of Photoenergy (2012)
13. Sonodynamic Therapy Using Dacarbazine-Loaded Ausio2 Nanoparticles for Melanoma Treatment: An In-Vitro Study on the B16f10 Murine Melanoma Cell Line, Ultrasound in Medicine and Biology (2022)
14. Destructive Effects of Therapeutic Ultrasound and Gold Nanoparticles on a Breast Carcinoma Tumor Model in Balb/C Mice, International Journal of Radiation Research (2020)
15. A Novel Nanosonosensitizer for Sonodynamic Therapy: In Vivo Study on a Colon Tumor Model, Journal of Ultrasound in Medicine (2011)
16. Evaluating the Effects of Ultrasound Waves on Mcf-7 Cells in the Presence of Ag Nanoparticles, Journal of Isfahan Medical School (2016)
17. An Overview of Therapeutic Applications of Ultrasound Based on Synergetic Effects With Gold Nanoparticles and Laser Excitation, Iranian Journal of Basic Medical Sciences (2019)
18. Nanoparticles on a Breast Carcinoma Tumor Model in Balb/C Mice, International Journal of Radiation Research (2020)
19. The Effect of Ultrasound Exposure in Combination With Gold Nanoparticles on Colonization of A375 and Mcf-7 Bystander Cells, Journal of Isfahan Medical School (2021)
20. Effect of Gold Nanoparticle Size on Acoustic Cavitation Using Chemical Dosimetry Method, Ultrasonics Sonochemistry (2017)
21. Investigating the Sonodynamic-Radiosensitivity Effect of Gold Nanoparticles on Hela Cervical Cancer Cells, Journal of Korean Medical Science (2019)
22. Green Synthesis of Bimetallic Zno–Cuo Nanoparticles and Their Cytotoxicity Properties, Scientific Reports (2021)
23. The Effect of Bystander Due to Combined Treatment of Ultrasound Waves and Cisplatin on Melanoma A375 Cell Line, Journal of Isfahan Medical School (2021)
24. Investigating the Effectiveness of 6 Mev Electron and Ultrasound Beams With the Use of Iron Oxide Magnetic Nanoparticles Attached to Cisplatin on B16f10 Cells: In-Vitro Study, International Journal of Nanoscience (2024)
25. Ultrasound Responsive Gd-Dota/Doxorubicin-Loaded Nanodroplet As a Theranostic Agent for Magnetic Resonance Image-Guided Controlled Release Drug Delivery of Melanoma Cancer, European Journal of Pharmaceutical Sciences (2022)
26. Evaluation of Sonochemiluminescence in a Phantom in the Presence of Protoporphyrin Ix Conjugated to Nanoparticles, Iranian Journal of Medical Physics (2012)
27. The Therapeutic Effect of Combination of X-Ray and Iron Oxide Nanoparticles Attached to Dacarbazine Chemotherapy Drug on Melanoma Cell Line, Journal of Isfahan Medical School (2022)
28. Bystander Effect of Therapeutic Ultrasound in the Presence of Cisplatin: An in Vitro Study on Human Melanoma Cells, Journal of Biomedical Physics and Engineering (2023)
29. Mn(Ii) & Gd(Iii) Deferrioxamine Complex Contrast Agents & Temozolomide Cancer Prodrug Immobilized on Folic Acid Targeted Graphene/Polyacrylic Acid Nanocarrier: Mri Efficiency, Drug Stability & Interactions With Cancer Cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2022)
30. Induction of a Bystander Effect After Therapeutic Ultrasound Exposure in Human Melanoma: In-Vitro Assay, International Journal of Radiation Research (2021)
31. In Vitro Study of Sonodynamic Therapy Using Gemcitabine-Loaded Peg-Gold Nanoparticles Against Mcf-7 Breast Cancer Cells, BioNanoScience (2024)
32. Gold Nanoparticle and Mean Inactivation Dose of Human Intestinal Colon Cancer Ht-29 Cells, Jundishapur Journal of Natural Pharmaceutical Products (2015)
33. Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review, Diagnostics (2023)
34. Detection of Sonoluminescence Signals in a Gel Phantom in the Presence of Protoporphyrin Ix Conjugated to Gold Nanoparticles, Ultrasonics (2013)
35. Skin Touch Effects of Gold Nanoparticles in Male Mice, Journal of Mazandaran University of Medical Sciences (2014)
36. Destruction of Melanoma Cells by Cold Atmospheric Plasma in the Presence of Gold Nanoparticles, Journal of Isfahan Medical School (2023)