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Alteration of Mir-21, Mir-433 and Mir-590 Tissue Expression Related to the Tgf-Β Signaling Pathway in Ulcerative Colitis Patients Publisher Pubmed



Naghdalipour M1 ; Moradi N2, 3 ; Fadaei R4 ; Rezghi Barez S5 ; Sayyahfar S1 ; Mokhtare M6 ; Fard TK7 ; Fallah S7 ; Esteghamati A1
Authors
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Authors Affiliations
  1. 1. Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of medical sciences, Tehran, Iran
  2. 2. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  3. 3. Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  4. 4. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Colorectal Research Center, Iran university of medical sciences, Tehran, Iran
  7. 7. Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2022


Abstract

Ulcerative colitis (UC) is an inflammatory disease, and studies have suggested a role for TGF-β signalling pathway in the pathogenesis of UC. In the present study, we evaluated expression of TGF-β signalling genes and their regulatory microRNAs in patients with UC and control subjects. The expression of TGF-β1, SMAD2, SMAD3, miR-21, miR-101, miR-433, and miR-590 were evaluated using real-time PCR in biopsy samples of the patients and controls. Results showed increased expression of TGF-β1 and SMAD3 in the patients compared to controls. In addition, miR-21 and miR-433 were found to be higher in the patients compared to controls; however, miR-590 was found to be lower. Moreover, miR-433 was demonstrated to have positive correlation with SMAD3 and TGF-β while miR-21 was positively correlated with TGF-β1. MiR-590 was negatively correlated with SMAD2 and SMAD3. Results of the present study suggested a role for TGF-β signalling pathway related microRNAs in pathogenesis of UC. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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