Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Mir-146A Is Deregulated in Gastric Cancer Publisher Pubmed



Adami B1 ; Tabatabaeian H2, 3 ; Ghaedi K4, 5 ; Talebi A6 ; Azadeh M7 ; Dehdashtian E1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Microbiology, Faculty of Biological Science, Islamic Azad University, Falavarjan Branch, Isfahan, Iran
  2. 2. Department of Biology, Division of Genetics, Faculty of Sciences, University of Isfahan, Iran
  3. 3. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  4. 4. Department of Biology, Division of Cellular and Molecular Biology, Faculty of Sciences, University of Isfahan, Isfahan, 81746-73441, Iran
  5. 5. Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Iran
  6. 6. Department of Pathology, School of Medicine, Isfahan University of Medical Science, Iran
  7. 7. Zist-Fanavari Novin Biotechnology Institute, Isfahan, Iran

Source: Journal of Cancer Research and Therapeutics Published:2019


Abstract

Background: Gastric cancer is one of the most significant reasons for cancer-related death. miR-146a is one of the dysregulated factors associated with gastric tumorigenesis. However, deregulation of this microRNA (miRNA) has become controversial. Moreover, the inflammation-mediating role of this miRNA implies that miR-146a might be dysregulated by gastric cancer-related pathogens, such as Helicobacter pylori. However, the dysregulation of miR-146a in H. pylori-infected gastric tumors has not been widely studied. Objectives: We aimed to analyze the expression level of miR-146a in gastric cancer tissues and then to assess any potential association between miR-146a and H. pylori infection and other clinical characteristics. Materials and Methods: miR-146a expression level was quantitatively studied by reverse transcription quantitative polymerase chain reaction, in 144 fresh tissues including 44 normal and 100 gastric cancer samples. Results: A dramatic overexpression of miR-146a was observed in primary gastric tumors. miR-146a showed lower expression in progressed tumors with greater stages and lymph node metastasis. Conclusion: miR-146a is highly expressed in primary gastric tumor independent of H. pylori infection. It is highly expressed in the lower stages and lymph node-negative tumors. It might suggest the importance of upregulation and downregulation of this miRNA in the initiating/promoting and progressive steps of gastric tumorigenesis, respectively. © 2019 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.
Related Docs
View other Related Docs
1. A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients, Gene Reports (2019)
2. Upregulation of Mir-222 in Both Helicobacter Pylori-Infected and Noninfected Gastric Cancer Patients, Journal of Genetics (2016)
3. Circulating Micrornas As Potential Diagnostic Biomarkers and Therapeutic Targets in Gastric Cancer: Current Status and Future Perspectives, Current Medicinal Chemistry (2016)
4. Mir-17-92 Host Gene, Uderexpressed in Gastric Cancer and Its Expression Was Negatively Correlated With the Metastasis, Indian Journal of Cancer (2015)
5. Mir-195 Down-Regulation Is a Distinctive Biomarker of Her2 Positive State in Breast Cancer, Gene Reports (2020)
6. What Are the Effects of Il-1Β (Rs1143634), Il-17A Promoter (Rs2275913) and Tlr4 (Rs4986790) Gene Polymorphism on the Outcomes of Infection With H. Pylori Within As Iranian Population; a Systematic Review and Meta-Analysis, Gene Reports (2020)
7. Effect of Pufas Oral Administration on the Amount of Apoptotic Caspases Enzymes in Gastric Cancer Patients Undergoing Chemotherapy, Anti-Cancer Agents in Medicinal Chemistry (2017)
8. Effects of Oral Butyrate and Inulin Supplementation on Inflammation-Induced Pyroptosis Pathway in Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, Cytokine (2020)
Experts (# of related papers)
View all Related Experts
Parvaneh Nikpour (12)
Mohammad Hossein Sanei (4)
Other Related Docs
9. Msi2 Expression Is Decreased in Grade Ii of Gastric Carcinoma, Pathology Research and Practice (2013)
10. Comprehensive Analysis of Ernas and Genes Involved in Gastric Cancer and Constructing a Prognostic Model Predicting the Overall Survival of Patients, Journal of Isfahan Medical School (2023)
11. Long Noncoding Rnas in Gastric Cancer Carcinogenesis and Metastasis, Briefings in Functional Genomics (2017)
12. The Importance of Snps at Mirna Binding Sites As Biomarkers of Gastric and Colorectal Cancers: A Systematic Review, Journal of Personalized Medicine (2022)
13. Virulence Factors of Helicobacter Pylori Vaca Increase Markedly Gastric Mucosal Tgf-Β1 Mrna Expression in Gastritis Patients, Microbial Pathogenesis (2014)
14. Lncarod Promotes the Proliferation and Migration of Gastric Cancer: A Bioinformatics Analysis and Experimental Validation, Functional and Integrative Genomics (2023)
15. The Interaction of Helicobacter Pylori Infection and Type 2 Diabetes Mellitus, Advanced Biomedical Research (2019)
16. Long Non-Coding Rnas As Potential Biomarkers or Therapeutic Targets in Gastric Cancer, Gastroenterology and Hepatology from Bed to Bench (2023)
17. Aberrant Expression of Plncrna-1 and Tug1: Potential Biomarkers for Gastric Cancer Diagnosis and Clinically Monitoring Cancer Progression, Biomarkers in Medicine (2017)
18. The Role of Mir-16 and Mir-34A Family in the Regulation of Cancers: A Review, Heliyon (2025)
19. Epstein-Barr Virus/Helicobacter Pylori Coinfection and Gastric Cancer: The Possible Role of Viral Gene Expression and Shp1 Methylation, Iranian Journal of Microbiology (2022)
20. Assessment of Microrna-146A in Generalized Aggressive Periodontitis and Its Association With Disease Severity, Journal of Periodontal Research (2019)
21. Comparison of Helicobacter Pylori and Escherichia Coli in Induction of Tnf-Α Mrna From Human Peripheral Blood Mononuclear Cells, Indian Journal of Medical Microbiology (2010)
22. A Review on Expression and Regulatory Mechanisms of Mir-337-3P in Cancer, Journal of Biomolecular Structure and Dynamics (2024)
23. Microrna Binding Site Polymorphism in Inflammatory Genes Associated With Colorectal Cancer: Literature Review and Bioinformatics Analysis, Cancer Gene Therapy (2020)
24. New Insight to Il-23/Il-17 Axis in Iranian Infected Adult Patients With Gastritis : Effects of Genes Polymorphisms on Expression of Cytokines, Acta Gastro-Enterologica Belgica (2015)
25. Mucosal Interleukin-21 Mrna Expression Level Is High in Patients With Helicobacter Pylori and Is Associated With the Severity of Gastritis, Central European Journal of Immunology (2015)
26. Association of Serum Microrna-21 Levels With Visfatin, Inflammation, and Acute Coronary Syndromes, Heart and Vessels (2017)
27. Alteration of Mir-21, Mir-433 and Mir-590 Tissue Expression Related to the Tgf-Β Signaling Pathway in Ulcerative Colitis Patients, Archives of Physiology and Biochemistry (2022)
28. Eya1 Expression in Gastric Carcinoma and Its Association With Clinicopathological Characteristics: A Pilot Study, Medical Oncology (2014)
29. Emerging Circulating Mirnas and Lncrnas in Upper Gastrointestinal Cancers, Expert Review of Molecular Diagnostics (2020)
30. Msi1 Overexpression in Diffuse Type of Gastric Cancer, Pathology Research and Practice (2013)
31. Evaluation of Mir-146A As a Potential Biomarker for Diagnosis of Cardiotoxicity Induced by Chemotherapy in Patients With Breast Cancer, Journal of Research in Medical Sciences (2025)
32. Identification of Cancer/Testis Antigens Related to Gastric Cancer Prognosis Based on Co-Expression Network and Integrated Transcriptome Analyses, Advanced Biomedical Research (2023)
33. Lactobacillus Rhamnosus and Lactobacillus Delbrueckii Ameliorate the Expression of Mir-125A and Mir-146A in Systemic Lupus Erythematosus Patients, Applied Biochemistry and Biotechnology (2024)
34. Construction of a Three-Component Regulatory Network of Transcribed Ultraconserved Regions for the Identification of Prognostic Biomarkers in Gastric Cancer, Journal of Cellular Biochemistry (2023)
35. A Comprehensive Review of the Role of Lncrnas in Gastric Cancer (Gc) Pathogenesis, Immune Regulation, and Their Clinical Applications, Pathology Research and Practice (2023)
36. Inhibition of Microrna Mir-92A Induces Apoptosis and Inhibits Cell Proliferation in Human Acute Promyelocytic Leukemia Through Modulation of P63 Expression, Molecular Biology Reports (2014)
37. Involvement of Single Nucleotide Polymorphisms in Acute Lymphoblastic Leukemia Susceptibility, Gene Reports (2020)
38. Microrna-184 in the Landscape of Human Malignancies: A Review to Roles and Clinical Significance, Cell Death Discovery (2023)
39. Correlation Between Mucosal Il-6 Mrna Expression Level and Virulence Factors of Helicobacter Pylori in Iranian Adult Patients With Chronic Gastritis, Jundishapur Journal of Microbiology (2015)
40. Down-Regulation of Circular Rna Itch and Circhipk3 in Gastric Cancer Tissues, Turkish Journal of Medical Sciences (2019)
41. Correlation of Caga Positive Helicobacter Pylori Infection With Clinical Outcomes in Alzahra Hospital, Isfahan, Iran, Journal of Research in Medical Sciences (2008)
42. Integrated Analysis of Transcriptome and Epigenome Reveals Ensr00000272060 As a Potential Biomarker in Gastric Cancer, Epigenomics (2024)