The Anti-Inflammatory and Antipyretic Effects of Clove Oil in Healthy Dogs After Surgery Publisher



Nikoui V^{1, 2} ; Ostadhadi S^{2, 3} ; Bakhtiarian A^{2, 4} ; Abbasigoujani E⁵ ; Habibiandehkordi S⁶ ; Rezaeiroshan M⁷ ; Foroohandeh M⁸ ; Giorgi M⁹
Source: PharmaNutrition Published:2017

Abstract

The current study was designed to evaluate the anti-inflammatory and antipyretic properties of clove oil in dogs. So thirty adult male dogs were used. After a surgical incision on the abdominal area, animals were divided into four group. The first group received 25 mg/kg of clove oil while the second group was considered as a control. The third and fourth groups received betamethasone (20 mg/kg) and phenylbutazone (15 mg/kg) as anti-inflammatory and anti-pyretic agents, respectively. All injections were performed for five consecutive days. All tests (measurement of edema, complete blood count, histopathology, and rectal temperature) were performed on all groups. Our results showed that in the clove oil-treated animals, the amount of edema was significantly decreased as compared to control (P ≤ 0.05). The number of white blood cells, neutrophils and band neutrophils was decreased in clove-oil treated dogs as compared to control (P ≤ 0.05). There was no significant difference in the number of red blood cells and hematocrit between clove-oil treated and vehicle-treated groups (P > 0.05). Rectal temperature significantly decreased in the clove oil-treated group as compared to control (P ≤ 0.05). Histopathology revealed that the clove oil-treatment significantly reduced the inflammation. We showed that clove oil administration has anti-inflammatory and antipyretic properties in dogs. © 2017 Elsevier B.V.