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Implementing Taguchi Method to Analyze Electrospinning Parameters Influence on Mg-Doped Fluorapatite Nanoparticles-Poly (Ε-Caprolactone) Nanocomposite Scaffold (Mg-Fa Nps/Pcl) Properties Publisher



Fereshteh Z1, 2, 3 ; Fathi M3, 4 ; Kargozar S5 ; Samadikuchaksaraei A6, 7, 8
Authors
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Authors Affiliations
  1. 1. Department of Biomedical Engineering, University of Delaware, Newark, DE, United States
  2. 2. Memorial Sloan Kettering Cancer Center, New York, NY, United States
  3. 3. Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran
  4. 4. Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Cellular and Molecular Research Center, IranUniversity of Medical Sciences, Tehran, Iran
  7. 7. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Polymers for Advanced Technologies Published:2020


Abstract

The present study focused on an investigation of significant electrospinning parameters on Mg-doped fluorapatite nanoparticles-poly (ε-caprolactone) fibrous nanocomposite scaffold (Mg-FA NPs/PCL). Since there are many factors that could have an influence on electrospinning process, Taguchi experimental design approach was used to reduce the number of experiments. The selected parameters included the concentration of polymer, solvent system, ceramic concentration, applied voltage, and the distance between nozzle and collector. The analysis of variance (ANOVA) showed that, among the studied parameters, polymer concentration and type of solvent had the most significant effect on the consistency of the solution which played a major role in producing uniform non-beaded fibers. In order to maximize performance of electrospun scaffold, the surface tension should be kept minimizing by decreasing concentration, applying a high dielectric solvent system, increasing voltage, and declining distance in a very stable electrical field. Eventually, the optimum condition to fabricate Mg-FA NPs/PCL fibrous scaffold was electrospinning 10 wt% PCL with 1 wt% Mg-FA NPs solution in chloroform by applying 20 kV into 20 cm distance. According to the bioactivity and cell attachment results, the electrospun Mg-FA NPs/PCL is suggested as a promising candidate for tissue engineering, especially for bone tissue. © 2020 John Wiley & Sons Ltd
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