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The Effects of Adjunctive Treatment With L-Carnitine on Monitoring Laboratory Variables in Icu Patients: A Double-Blinded Randomized Controlled Clinical Trial Publisher Pubmed



Yahyapoor F1 ; Keshani M2, 3 ; Sedaghat A4 ; Feizi A5 ; Clark CCT6 ; Bagherniya M2, 3, 7 ; Safarian M1 ; Badpeyma M8, 9 ; Norouzy A1
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Biostatistics and Epidemiology Department, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, United Kingdom
  7. 7. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Trials Published:2023


Abstract

Background: Critically ill patients must be monitored constantly in intensive care units (ICUs). Among many laboratory variables, nutritional status indicators are a key role in the prognosis of diseases. We investigated the effects of l-carnitine adjunctive therapy on monitoring variables in critical illness. Method: A prospective, double-blind, randomized controlled trial was implemented in a medical ICU. Participants were 54 patients, aged > 18 years, with multiple conditions, randomly assigned to receive 3 g l-carnitine per day or placebo, along with enteral feeding, for 1 week. Primary outcomes included monitoring variables related to nutritional status. Result: Of 54 patients randomly assigned, 51 completed the trial. Serum albumin (Alb) (P-value: 0.001), total protein (P-value: 0.003), and calcium (Ca) (0.044) significantly increased in the intervention vs. control group. Alanine transaminase (ALT) (0.022), lactate (<0.001), creatinine (Cr) (0.005), and international normalized ratio (INR) (0.049) decreased meaningfully in the intervention vs. control group. Conclusion: l-Carnitine supplementation in critically ill patients can improve several parameters including INR, Cr, ALT, lactate, Ca, Alb, and total protein. Trial registration: Iranian Registry of Clinical Trials IRCT 20151108024938N2. This trial was approved by the Research Ethics Committee of Mashhad University of Medical Sciences (registration code: IR.MUMS.fm.REC.1396.671) (available at https://en.irct.ir/trial/30748, May 2018). © 2023, The Author(s).
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