Skin Touch Effects of Gold Nanoparticles in Male Mice



Ghahnavieh MZ¹ ; Ghahnavieh MZ¹ ; Naghsh N³ ; Dorostkar E¹ Show Affiliations
Source: Journal of Mazandaran University of Medical Sciences Published:2014

Abstract

Background and purpose: Despite relative neutrality of metal gold in chemistry reactions, there is a concern about skin absorption and toxicity of gold nanoparticles that nowadays are increasingly used around us. On the other hand, judging from liver detoxification, in this study, the histological alterations of liver and their enzymes and blood cells were investigated in mice by touch of gold nanoparticles. Material and Methods: The backs of 32 male mice were shaved and then were divided into control group in which their back skins were touched with 0.2ml/day distilled water and 3 groups (25, 50,100 ppm) that were being treated with 0.2 ml/day of gold nanoparticles with mentioned doses and 10 nm diameter for 14 days. Finally, their blood was taken for hematology and biochemistry tests and their livers were removed for histopathology tests. Results: To compare the liver tissues of the control group with 3 other groups showed some abnormalities in liver tissues of all treated groups that in 50 & 100 ppm were significant. The levels of two liver enzymes (ALT,AST) and CBC (complete blood count) of control group in comparison with 3 other groups showed that ALT enzyme levels in 50 &100 ppm groups had increased but the levels of ALT & AST in other groups decreased (not significant) and also the values of CBC test showed no significant differences. Conclusion: Touch of gold nanoparticles and conditions of this study has toxic effect on the liver of male mice. So, this has a hazard potential.