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Scolicidal Agents for Protoscolices of Echinococcus Granulosus Hydatid Cyst: Review of Literature Publisher



Sharafi SM1 ; Sefiddashti RR2 ; Sanei B3 ; Yousefi M4 ; Darani HY2
Authors
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Authors Affiliations
  1. 1. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Hepatobiliary Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Surgery, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: Journal of Research in Medical Sciences Published:2017


Abstract

Hydatid cyst is the larval stage of dog tape worm Echinococcus granulosus. Protoscolices are parasite larvae that develop into adult worms in the final host intestine. During surgical treatment of human hydatidsosis spillage of live protoscolices is the major cause of hydatidosis recurrence. To prevent this problem scolicidal agent such as hypertonic salt are used to kill the protoscolices that may disseminate into the patient’s tissues during surgery. However, they may have some unacceptable side effects. To find scolicidal agents with high efficacy, the effect of different compounds on protoscolices of hydatid cyst in vitro has been reviewed. Using PubMed, Scopus, Google Scholar, and SID databases articles about scolicidal effects of different agents on protoscolices of hydatid cyst in vitro were collected. Foeniculum vulgare after 5 min, metalonic extracts of Allium sativum and hypertonic saline after 10 min, and warm water after 2 min kill all alive protoscolices. The above agents that in minimum time and minimum concentration have 100% scolicidal activity, could be good candidates for further investigations. © 2017 Journal of Research in Medical Sciences.
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