Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Inhibition of Mouse Colon Cancer Growth Following Immunotherapy With a Fraction of Hydatid Cyst Fluid Publisher Pubmed



Rostamirad S1, 4 ; Daneshpour S1 ; Mofid MR2 ; Andalib A3 ; Eskandariyan A1 ; Mousavi S1 ; Yousofi Darani H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Parasitology and Mycology, Isfahan Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biochemistry, Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Immunology Department, Isfahan Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Clinical Research Development Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran

Source: Experimental Parasitology Published:2023


Abstract

Background: Hydatid cyst is the larval stage of the tape worm Echinococcus granulosus which is located in human and livestock viscera. There are some scientific evidences indicating that parasitic infections induce antitumor activity against certain types of cancers. In this study, the effects of a fraction of hydatid cyst fluid on colon cancer tumor in BALB/c mice were investigated. Materials and methods: In this experimental work six groups of mice were challenged with mouse colon cancer cells. 5 days later when the sign of tumor growth in mice was seen, group 1–4 were injected with hydatid cyst fluid, the 78 kDa fraction, live protoscolices and BCG respectively. Group five was injected with alum alone and the sixth group left intact without any injection. The size of the tumor was measured and compared in all groups. Then blood samples of mice were evaluated for serum cytokine levels. Result: In mice injected with hydatid cyst antigens especially a fraction of hydatid cyst fluid, tumor size was smaller than the that of control groups and the difference of tumor size in cases and control groups was statistically significant. Conclusion: The results of this study showed that injection of mice with a fraction of hydatid cyst fluid significantly inhibits the growth of mouse colon cancer and this inhibition may be related to effect of immune response to these antigens. © 2023 Elsevier Inc.
Related Docs
View other Related Docs
1. Effect of Two Hydatid Cyst Antigens on the Growth of Melanoma Cancer in C57/Black Mice, Journal of Parasitic Diseases (2016)
2. Effect of Alive Protoscoleces of Hydatid Cyst on the Growth of Melanoma Cells in Mouse Model, Journal of Isfahan Medical School (2014)
3. Effect of Hydatid Cyst Antigens on Inhibition of Melanoma Cancer Growth in Mouse Model, Cellular and Molecular Biology (2018)
4. Anti-Cancer Immunoprotective Effects of Immunization With Hydatid Cyst Wall Antigens in a Non-Immunogenic and Metastatic Triple-Negative Murine Mammary Carcinoma Model, International Immunopharmacology (2021)
5. Effect of Hydatid Cyst Antigens Polyspecific Antisera on Breast Cancer Cells (4T1) Growth in Cell Culture Medium, International Journal of Environmental Health Engineering (2022)
6. Parasites and Cancers: Parasite Antigens As Possible Targets for Cancer Immunotherapy, Future Oncology (2012)
7. Monoclonal Antibodies Production Against a 40Kda Band of Hydatid Cyst Fluid, Recent Patents on Biotechnology (2018)
8. Anti-Toxoplasma Gondii Antibodies Attach to Mouse Cancer Cell Lines But Not Normal Mouse Lymphocytes, Biomedical Reports (2019)
Experts (# of related papers)
View all Related Experts
Hossein Yousofi Darani (28)
Zahra Ghayour Najafabadi (6)
Other Related Docs
9. Investigating the Reaction of Antisera Against Hydatid Cyst Antigens With the Surface of Breast Cancer (4T1), Melanoma (B16f10), and Normal Spleen Cells Using Flow Cytometry Technique, Journal of Isfahan Medical School (2018)
10. Identifying the Most Effective Hydatid Cyst Fluid Fraction for Anticancer Vaccination of 4T1 Breast Tumor-Bearing Mice, International Journal of Preventive Medicine (2019)
11. Parasites As Potential Targets for Cancer Immunotherapy, Journal of Cancer Research and Clinical Oncology (2023)
12. Mutual Action of Anticancer and Antiparasitic Drugs: Are There Any Shared Targets?, Future Oncology (2014)
13. Effects of Toxoplasma Gondii and Toxocara Canis Antigens on Wehi-164 Fibrosarcoma Growth in a Mouse Model, Korean Journal of Parasitology (2009)
14. Low Titer of Antibody Against Toxoplasma Gondii May Be Related to Resistant to Cancer, Journal of Cancer Research and Therapeutics (2015)
15. Parasites and Immunotherapy: With or Against?, Journal of Parasitic Diseases (2016)
16. Effect of Hydatid Cyst Fluid Antigens on Induction of Apoptosis on Breast Cancer Cells, Advanced Biomedical Research (2019)
17. Human Anti-Toxoplasma Antibodies Attach Strongly to Breast Cancer Cells, International Journal of Cancer Management (2023)
18. Immunohistochemical Observation of Local Inflammatory Cell Infiltration in the Host-Tissue Reaction Site of Human Hydatid Cysts, Journal of Helminthology (2019)
19. Scolicidal Agents for Protoscolices of Echinococcus Granulosus Hydatid Cyst: Review of Literature, Journal of Research in Medical Sciences (2017)
20. Diagnostic Value of Hydatid Cyst Antigens Using Western Blotting Method, Jundishapur Journal of Microbiology (2010)
21. Immunological Diagnosis of Human Hydatid Cyst Using Western Immunoblotting Technique, Journal of Research in Medical Sciences (2016)
22. Apoptosis Genes Expression in Bovine Lymphocytes in Response to Fertile and Infertile Hydatid Cyst Fluid, Journal of Veterinary Research (2019)
23. Expression of Matrix Metalloproteinases in Human Cystic Echinococcosis, Current Molecular Medicine (2024)
24. A Comparative Evaluation of Hematological, Biochemical and Pathological Changes Among Infected Sheep With Cysticercus Tenuicollis and Non-Infected Control Group, Journal of Parasitic Diseases (2014)
25. Histopathological Study on Fibrous Layer of Hydatid Cyst in Camel, Cattle and Sheep, Journal of Isfahan Medical School (2016)
26. Albendazole and Treatment of Hydatid Cyst: Review of the Literature, Infectious Disorders - Drug Targets (2019)
27. Immunization of Sheep Against Echinococcus Granulosus With Protoscolex Tegumental Surface Antigens, Veterinary World (2017)
28. Molecular Characterization of Human and Animal Echinococcus Granulosus Isolates in Isfahan, Iran, Acta Tropica (2011)
29. Echhinococcus Granulosus Lnfection in Mice Following Lmmunization With Protoscoleces Antigens, Journal of Isfahan Medical School (2009)
30. Antibody Response to Glycan Antigens of Hydatid Cyst Fluid, Laminated Layer and Protoscolex of Echinococcus Granulosus, Medical Journal of the Islamic Republic of Iran (2017)
31. A Survey on Apoptosis and Hydatid Cyst Infertility, Journal of Isfahan Medical School (2021)
32. Stability Determination of Recombinant Echinococcus Granulosus Antigen B Kit by Physical and Bacteriostatical Methods, Journal of Isfahan Medical School (2013)
33. Evaluating the Gene Expression Level of Il-12 in the Fibrous Layer of Hepatic Hydatid Cysts Isolated From Slaughtered Animals, Comparative Clinical Pathology (2015)
34. Diagnostic Value of Echinococcus Granulosus Recombinant Protein B-Containing Kit in Comparison With the Euroimmun Kit, Journal of Isfahan Medical School (2013)
35. Il-4 Gene Expression in Adventitial Layer (Fibrous Layer) of Hepatic Ovine and Bovine Hydatid Cysts, Journal of Parasitic Diseases (2016)
36. Overview of Hydatid Disease in Iranian Children, Archives of Pediatric Infectious Diseases (2015)
37. Th1/Th2-Type Cytokine Profile in C57 Black Mice Inoculated With Live Echinococcus Granulosus Protoscolices, Journal of Infection and Public Health (2018)
38. Apoptosis As a Potential Target to Arrest and Survival of Hydatid Cyst, Advanced Biomedical Research (2023)
39. Bio-Membrane Selex As a New Approach for Selecting Ss-Dna Aptamers That Bind to the Hydatid Cyst Laminated Layer, Current Molecular Medicine (2023)