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Unraveling the Molecular Landscape of Osteoarthritis: A Comprehensive Review Focused on the Role of Non-Coding Rnas Publisher Pubmed



Shakeri M1 ; Aminian A1 ; Mokhtari K2 ; Bahaeddini M1 ; Tabrizian P1 ; Farahani N3 ; Nabavi N4 ; Hashemi M5, 6
Authors
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Authors Affiliations
  1. 1. MD, Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
  3. 3. Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Independent Researcher, Victoria, V8V 1P7, BC, Canada
  5. 5. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  6. 6. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: Pathology Research and Practice Published:2024


Abstract

Osteoarthritis (OA) poses a significant global health challenge, with its prevalence anticipated to increase in the coming years. This review delves into the emerging molecular biomarkers in OA pathology, focusing on the roles of various molecules such as metabolites, noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Advances in omics technologies have transformed biomarker identification, enabling comprehensive analyses of the complex pathways involved in OA pathogenesis. Notably, ncRNAs, especially miRNAs and lncRNAs, exhibit dysregulated expression patterns in OA, presenting promising opportunities for diagnosis and therapy. Additionally, the intricate interplay between epigenetic modifications and OA progression highlights the regulatory role of epigenetics in gene expression dynamics. Genome-wide association studies have pinpointed key genes undergoing epigenetic changes, providing insights into the inflammatory processes and chondrocyte hypertrophy typical of OA. Understanding the molecular landscape of OA, including biomarkers and epigenetic mechanisms, holds significant potential for developing innovative diagnostic tools and therapeutic strategies for OA management. © 2024 Elsevier GmbH
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