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Modulation of Long Non-Coding Rnas by Resveratrol As a Potential Therapeutic Approach in Cancer: A Comprehensive Review Publisher Pubmed



Asemi R1 ; Rajabpoor Nikoo N2 ; Asemi Z3 ; Shafabakhsh R3 ; Hajijafari M4 ; Sharifi M1 ; Homayoonfal M3 ; Davoodvandi A5 ; Hakamifard A6
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Department of Anesthesiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  6. 6. Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Pathology Research and Practice Published:2023


Abstract

LncRNAs, or long non-coding RNAs, are a subset of RNAs that play a regulatory role in a wide range of biological functions, including RNA processing, epigenetic regulation, and signal transduction. Recent research indicates that lncRNAs play a key role in the development and spread of cancer by being dysregulated in the disease. In addition, lncRNAs have been linked to the overexpression of certain proteins that are involved in tumor development and progression. Resveratrol has anti-inflammatory and anti-cancer properties that it exerts through regulating different lncRNAs. By the regulation of tumor-supportive and tumor-suppressive lncRNAs, resveratrol acts as an anti-cancer agent. By downregulating the tumor-supportive lncRNAs DANCR, MALAT1, CCAT1, CRNDE, HOTAIR, PCAT1, PVT1, SNHG16, AK001796, DIO3OS, GAS5 and H19, and upregulating MEG3, PTTG3P, BISPR, PCAT29, GAS5, LOC146880, HOTAIR, PCA3, NBR2, this herbal remedy causes apoptosis and cytotoxicity. For the purpose of using polyphenols in cancer therapy, it would be helpful to have more in-depth knowledge about lncRNA modulation via resveratrol. Here, we discuss the current knowledge and future promise of resveratrol as modulators of lncRNAs in different cancers. © 2023 Elsevier GmbH
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