Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria

Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria Publisher Pubmed

Philippot Q^{1, 2} ; Ogishi M³ ; Bohlen J^{1, 2} ; Puchan J⁴ ; Arias AA^{3, 5, 6} ; Nguyen T^{7, 8} ; Martinfernandez M^{9, 10, 11, 12, 13} ; Conil C^{1, 2} ; Rinchai D³ ; Momenilandi M^{1, 2} ; Mahdaviani SA¹⁴ ; Keramatipour M¹⁵ ; Rosain J^{1, 2} ; Yang R³ Show All Authors

Philippot Q^{1, 2}
Ogishi M³
Bohlen J^{1, 2}
Puchan J⁴
Arias AA^{3, 5, 6}
Nguyen T^{7, 8}
Martinfernandez M^{9, 10, 11, 12, 13}
Conil C^{1, 2}
Rinchai D³
Momenilandi M^{1, 2}
Mahdaviani SA¹⁴
Keramatipour M¹⁵
Rosain J^{1, 2}
Yang R³
Khan T¹⁶
Neehus AL^{1, 2}
Materna M^{1, 2}
Han JE³
Peel J³
Mele F¹⁷
Weisshaar M⁴
Jovic S¹⁷
Bastard P^{1, 2, 3, 18}
Levy R^{1, 2, 18}
Le Voyer T^{1, 2}
Zhang P³
Renkilaraj MRLM^{1, 2}
Arangofranco CA^{1, 5}
Pelham S³
Seeleuthner Y^{1, 2}
Pochon M^{1, 2}
Ata MMA¹⁶
Al Ali F¹⁶
Migaud M^{1, 2}
Soudee C^{1, 2}
Kochetkov T³
Molitor A^{19, 20}
Carapito R^{19, 20, 21}
Bahram S^{19, 20, 21}
Boisson B^{1, 2, 3}
Fieschi C²²
Mansouri D^{14, 23}
Marr N^{16, 24, 25}
Okada S²⁶
Shahrooei M^{27, 28}
Parvaneh N²⁹
Chavoshzadeh Z³⁰
Cobat A^{1, 2, 3}
Bogunovic D^{10, 11, 12, 13, 14}
Abel L^{1, 2, 3}
Tangye SG^{8, 9}
Ma CS^{8, 9}
Beziat V^{1, 2, 3}
Sallusto F^{4, 17}
Boissondupuis S^{1, 2, 3}
Bustamante J^{1, 2, 3, 31}
Casanova JL^{1, 2, 3, 32, 33}
Puel A^{1, 2, 3}

Show Affiliations

1. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France
2. University Paris Cite, Imagine Institute, Paris, France
3. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, United States
4. Institute of Microbiology, ETH Zurich, Zurich, Switzerland
5. Primary Immunodeficiencies Group, University of Antioquia (UdeA), Medellin, Colombia
6. School of Microbiology, University of Antioquia (UdeA), Medellin, Colombia
7. Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
8. School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia
9. Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, United States
10. Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
11. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
12. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States
13. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
14. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
15. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
16. Department of Human Immunology, Sidra Medicine, Doha, Qatar
17. Institute for Research in Biomedicine, Universita della Svizzera italiana, Bellinzona, Switzerland
18. Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France
19. Molecular Immuno-Rheumatology Laboratory, INSERM UMR_S1109, GENOMAX Platform, Faculty of Medicine, OMICARE University Hospital Federation, Immunology and Hematology Research Center, Research Center in Biomedicine of Strasbourg (CRBS), Federation of Translational Medicine of Strasbourg (FMTS), University of Strasbourg, Strasbourg, France
20. Interdisciplinary Thematic Institute (ITI) of Precision Medicine of Strasbourg, Strasbourg, France
21. Immunology Laboratory, Biology Technical Platform, Biology Pole, New Civil Hospital, Strasbourg, France
22. Clinical Immunology Department, Saint Louis Hospital, Paris, France
23. Clinical Tuberculosis and Epidemiology Research Centre, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran
24. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar
25. Institute of Translational Immunology, Brandenburg Medical School, Brandenburg an der Havel, Germany
26. Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-Ku, Hiroshima-Shi, Hiroshima, Japan
27. Clinical and Diagnostic Immunology, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Belgium
28. Dr. Shahrooei Lab, 22 Bahman St., Ashrafi Esfahni Blvd, Teheran, Iran
29. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Childrenâ€™s Medical Center, Tehran University of Medical Sciences, Teheran, Iran
30. Pediatric Infections Research Center, Mofid Childrenâ€™s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
31. Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, Paris, France
32. Howard Hughes Medical Institute, New York, NY, United States
33. Department of Pediatrics, Necker Hospital for Sick Children, Paris, France

Source: Science Immunology Published:2023

Abstract

Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less commonly, chronic mucocutaneous candidiasis (CMC) due to impaired IL-17A/F production. We report six patients from four kindreds with AR IL-23R deficiency. These patients are homozygous for one of four different loss-of-function IL23R variants. All six patients have a history of MSMD, but only two suffered from CMC. We show that IL-23 induces IL-17A only in MAIT cells, possibly contributing to the incomplete penetrance of CMC in patients unresponsive to IL-23. By contrast, IL-23 is required for both baseline and Mycobacterium-inducible IFN-γ immunity in both Vδ2+ γδ T and MAIT cells, probably contributing to the higher penetrance of MSMD in these patients. Human IL-23 appears to contribute to IL-17A/F–dependent immunity to Candida in a single lymphocyte subset but is required for IFN-γ–dependent immunity to Mycobacterium in at least two lymphocyte subsets. Copyright © 2023 The Authors, some rights reserved.

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Style	Citing Format
MLA	Philippot Q, et al.. "Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria." Science Immunology, vol. 8, no. 80, 2023, pp. -.
APA	Philippot Q, Ogishi M, Bohlen J, Puchan J, Arias AA, Nguyen T, Martinfernandez M, Conil C, Rinchai D, Momenilandi M, Mahdaviani SA, Keramatipour M, Rosain J, Yang R, Khan T, Neehus AL, Materna M, Han JE, Peel J, ... Puel A (2023). Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria. Science Immunology, 8(80), -.
Chicago	Philippot Q, Ogishi M, Bohlen J, Puchan J, Arias AA, Nguyen T, Martinfernandez M, et al.. "Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria." Science Immunology 8, no. 80 (2023): -.
Harvard	Philippot Q et al. (2023) 'Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria', Science Immunology, 8(80), pp. -.
Vancouver	Philippot Q, Ogishi M, Bohlen J, Puchan J, Arias AA, Nguyen T, et al.. Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria. Science Immunology. 2023;8(80):-.
BibTex	@article{ author = {Philippot Q and Ogishi M and Bohlen J and Puchan J and Arias AA and Nguyen T and Martinfernandez M and Conil C and Rinchai D and Momenilandi M and Mahdaviani SA and Keramatipour M and Rosain J and Yang R and Khan T and Neehus AL and Materna M and Han JE and Peel J and Mele F and Weisshaar M and Jovic S and Bastard P and Levy R and Le Voyer T and Zhang P and Renkilaraj MRLM and Arangofranco CA and Pelham S and Seeleuthner Y and Pochon M and Ata MMA and Al Ali F and Migaud M and Soudee C and Kochetkov T and Molitor A and Carapito R and Bahram S and Boisson B and Fieschi C and Mansouri D and Marr N and Okada S and Shahrooei M and Parvaneh N and Chavoshzadeh Z and Cobat A and Bogunovic D and Abel L and Tangye SG and Ma CS and Beziat V and Sallusto F and Boissondupuis S and Bustamante J and Casanova JL and Puel A}, title = {Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria}, journal = {Science Immunology}, volume = {8}, number = {80}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Philippot Q AU - Ogishi M AU - Bohlen J AU - Puchan J AU - Arias AA AU - Nguyen T AU - Martinfernandez M AU - Conil C AU - Rinchai D AU - Momenilandi M AU - Mahdaviani SA AU - Keramatipour M AU - Rosain J AU - Yang R AU - Khan T AU - Neehus AL AU - Materna M AU - Han JE AU - Peel J AU - Mele F AU - Weisshaar M AU - Jovic S AU - Bastard P AU - Levy R AU - Le Voyer T AU - Zhang P AU - Renkilaraj MRLM AU - Arangofranco CA AU - Pelham S AU - Seeleuthner Y AU - Pochon M AU - Ata MMA AU - Al Ali F AU - Migaud M AU - Soudee C AU - Kochetkov T AU - Molitor A AU - Carapito R AU - Bahram S AU - Boisson B AU - Fieschi C AU - Mansouri D AU - Marr N AU - Okada S AU - Shahrooei M AU - Parvaneh N AU - Chavoshzadeh Z AU - Cobat A AU - Bogunovic D AU - Abel L AU - Tangye SG AU - Ma CS AU - Beziat V AU - Sallusto F AU - Boissondupuis S AU - Bustamante J AU - Casanova JL AU - Puel A TI - Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria JO - Science Immunology VL - 8 IS - 80 SP - EP - PY - 2023 ER -

Style

Citing Format

MLA

Philippot Q, et al.. "Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria." Science Immunology, vol. 8, no. 80, 2023, pp. -.

APA

Philippot Q, Ogishi M, Bohlen J, Puchan J, Arias AA, Nguyen T, Martinfernandez M, Conil C, Rinchai D, Momenilandi M, Mahdaviani SA, Keramatipour M, Rosain J, Yang R, Khan T, Neehus AL, Materna M, Han JE, Peel J, ... Puel A (2023). Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria. Science Immunology, 8(80), -.

Chicago

Philippot Q, Ogishi M, Bohlen J, Puchan J, Arias AA, Nguyen T, Martinfernandez M, et al.. "Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria." Science Immunology 8, no. 80 (2023): -.

Harvard

Philippot Q et al. (2023) 'Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria', Science Immunology, 8(80), pp. -.

Vancouver

Philippot Q, Ogishi M, Bohlen J, Puchan J, Arias AA, Nguyen T, et al.. Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria. Science Immunology. 2023;8(80):-.

BibTex

@article{ author = {Philippot Q and Ogishi M and Bohlen J and Puchan J and Arias AA and Nguyen T and Martinfernandez M and Conil C and Rinchai D and Momenilandi M and Mahdaviani SA and Keramatipour M and Rosain J and Yang R and Khan T and Neehus AL and Materna M and Han JE and Peel J and Mele F and Weisshaar M and Jovic S and Bastard P and Levy R and Le Voyer T and Zhang P and Renkilaraj MRLM and Arangofranco CA and Pelham S and Seeleuthner Y and Pochon M and Ata MMA and Al Ali F and Migaud M and Soudee C and Kochetkov T and Molitor A and Carapito R and Bahram S and Boisson B and Fieschi C and Mansouri D and Marr N and Okada S and Shahrooei M and Parvaneh N and Chavoshzadeh Z and Cobat A and Bogunovic D and Abel L and Tangye SG and Ma CS and Beziat V and Sallusto F and Boissondupuis S and Bustamante J and Casanova JL and Puel A}, title = {Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria}, journal = {Science Immunology}, volume = {8}, number = {80}, pages = {-}, year = {2023} }

RIS

TY - JOUR
AU - Philippot Q
AU - Ogishi M
AU - Bohlen J
AU - Puchan J
AU - Arias AA
AU - Nguyen T
AU - Martinfernandez M
AU - Conil C
AU - Rinchai D
AU - Momenilandi M
AU - Mahdaviani SA
AU - Keramatipour M
AU - Rosain J
AU - Yang R
AU - Khan T
AU - Neehus AL
AU - Materna M
AU - Han JE
AU - Peel J
AU - Mele F
AU - Weisshaar M
AU - Jovic S
AU - Bastard P
AU - Levy R
AU - Le Voyer T
AU - Zhang P
AU - Renkilaraj MRLM
AU - Arangofranco CA
AU - Pelham S
AU - Seeleuthner Y
AU - Pochon M
AU - Ata MMA
AU - Al Ali F
AU - Migaud M
AU - Soudee C
AU - Kochetkov T
AU - Molitor A
AU - Carapito R
AU - Bahram S
AU - Boisson B
AU - Fieschi C
AU - Mansouri D
AU - Marr N
AU - Okada S
AU - Shahrooei M
AU - Parvaneh N
AU - Chavoshzadeh Z
AU - Cobat A
AU - Bogunovic D
AU - Abel L
AU - Tangye SG
AU - Ma CS
AU - Beziat V
AU - Sallusto F
AU - Boissondupuis S
AU - Bustamante J
AU - Casanova JL
AU - Puel A
TI - Human Il-23 Is Essential for Ifn-Γ–Dependent Immunity to Mycobacteria
JO - Science Immunology
VL - 8
IS - 80
SP -
EP -
PY - 2023
ER -

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