Low Prevalence of Antifungal Resistant Candida Africana, in the C. Albicans Complex Causing Vulvovaginal Candidiasis

Low Prevalence of Antifungal Resistant Candida Africana, in the C. Albicans Complex Causing Vulvovaginal Candidiasis Publisher

Farahyar S^{1, 2} ; Izadi S² ; Razmjou E² ; Falahati M² ; Roudbary M² ; Ashrafikhozani M² ; Ansari S³ ; Fattahi A⁴ ; Ghahrimobaser Z⁵ ; Rahimi M⁶

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1. Microbial Biotechnology Research Center (MBiRC), Iran University of Medical Sciences, Tehran, Iran
2. Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti, University of Medical Sciences, Tehran, Iran
4. Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
5. International Campus, Iran University of Medical Sciences, Tehran, Iran
6. Department of Gynecology, Shahid Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran

Source: Heliyon Published:2020

Abstract

The Candida (C.) albicans complex includes C. albicans, C. dubliniensis, C. stellatoidea, and C. africana, with the last mentioned as an important emerging agent of vulvovaginal candidiasis (VVC). The aim of the study was to identify C. africana and C. dubliniensis and assess their drug susceptibility in vaginitis. One-hundred Candida isolates of the C. albicans complex from women diagnosed with vaginitis and from vaginal samples in the culture collection of a medical mycology laboratory were examined. Species of the C. albicans complex were identified with conventional and molecular methods using polymerase chain reaction (PCR) for amplification and sequencing of the internal transcribed spacer (ITS) region, PCR for partial amplification of hyphal wall protein 1 (HWP1) gene and duplex PCR. The effects of antifungal drugs were evaluated according to standard broth microdilution protocols. Ninety-seven C. albicans (97%) and three C. africana (3%) isolates were identified. Results of susceptibility testing revealed one isolate of C. africana to be resistant to both clotrimazole and fluconazole, and one showed reduced susceptibility to itraconazole. Identification of Candida species especially C. africana in vaginitis is crucial, there are varying levels of resistance to antifungal drugs. © 2020; Microbiology; Mycology; Microbial genomics; DNA sequencing; Antimicrobial; Women's health; Candida albicans complex; Candida dubliniensis; Candida africana; Drug susceptibility; Vulvovaginal candidiasis; HWP1. © 2020

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Mahsa Fattahi (2)

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Style	Citing Format
MLA	Farahyar S, et al.. "Low Prevalence of Antifungal Resistant Candida Africana, in the C. Albicans Complex Causing Vulvovaginal Candidiasis." Heliyon, vol. 6, no. 3, 2020, pp. -.
APA	Farahyar S, Izadi S, Razmjou E, Falahati M, Roudbary M, Ashrafikhozani M, Ansari S, Fattahi A, Ghahrimobaser Z, Rahimi M (2020). Low Prevalence of Antifungal Resistant Candida Africana, in the C. Albicans Complex Causing Vulvovaginal Candidiasis. Heliyon, 6(3), -.
Chicago	Farahyar S, Izadi S, Razmjou E, Falahati M, Roudbary M, Ashrafikhozani M, Ansari S, Fattahi A, Ghahrimobaser Z, Rahimi M. "Low Prevalence of Antifungal Resistant Candida Africana, in the C. Albicans Complex Causing Vulvovaginal Candidiasis." Heliyon 6, no. 3 (2020): -.
Harvard	Farahyar S et al. (2020) 'Low Prevalence of Antifungal Resistant Candida Africana, in the C. Albicans Complex Causing Vulvovaginal Candidiasis', Heliyon, 6(3), pp. -.
Vancouver	Farahyar S, Izadi S, Razmjou E, Falahati M, Roudbary M, Ashrafikhozani M, et al.. Low Prevalence of Antifungal Resistant Candida Africana, in the C. Albicans Complex Causing Vulvovaginal Candidiasis. Heliyon. 2020;6(3):-.
BibTex	@article{ author = {Farahyar S and Izadi S and Razmjou E and Falahati M and Roudbary M and Ashrafikhozani M and Ansari S and Fattahi A and Ghahrimobaser Z and Rahimi M}, title = {Low Prevalence of Antifungal Resistant Candida Africana, in the C. Albicans Complex Causing Vulvovaginal Candidiasis}, journal = {Heliyon}, volume = {6}, number = {3}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Farahyar S AU - Izadi S AU - Razmjou E AU - Falahati M AU - Roudbary M AU - Ashrafikhozani M AU - Ansari S AU - Fattahi A AU - Ghahrimobaser Z AU - Rahimi M TI - Low Prevalence of Antifungal Resistant Candida Africana, in the C. Albicans Complex Causing Vulvovaginal Candidiasis JO - Heliyon VL - 6 IS - 3 SP - EP - PY - 2020 ER -

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