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Biomaterials and Stem Cells As Drug/Gene-Delivery Vehicles for Parkinson's Treatment: An Update Publisher Pubmed



Roshani M1, 2 ; Kiaie N3 ; Aghdam RM1
Authors
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Authors Affiliations
  1. 1. School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, 11155-4563, Iran
  2. 2. Department of Biomedical Engineering, Shahab Danesh University, Qom, Iran
  3. 3. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Regenerative Medicine Published:2021


Abstract

By introducing biomaterials and stem cells into Parkinson's disease (PD), therapeutic approaches have led to promising results due to facilitating brain targeting and blood-brain barrier permeation of the drugs and genes. Here, after reviewing the most recent drug-and gene-delivery vehicles including liposomes, exosomes, natural/synthetic polymeric particles/fibers, metallic/ceramic nanoparticles and microbubbles, used for Parkinson's disease treatment, the effect of stem cells as a reservoir of neurotrophic factors and exosomes is provided. © 2021 Future Medicine Ltd.
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