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Emerging Stem Cell Therapy and Tissue Engineering-Based Approaches in Neurodegenerative Diseases Publisher



Khaboushan AS1, 2 ; Sadeghmousavi S2, 3 ; Kajbafzadeh AM2
Authors
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Authors Affiliations
  1. 1. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Pediatric Urology and Regenerative Medicine Research Center, Gene, Cell and Tissue Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Handbook of Stem Cell Applications Published:2024


Abstract

Neurodegenerative diseases are a set of disorders with an increasing prevalence caused by the continuous loss of functional neurons. Treatment of neurodegenerative diseases has remained complicated due to the limited regenerative capacity of neural tissues; hence, the available therapeutic approaches are not resolute and primarily focus on resolving the symptoms. The application of tissue engineering brought new hopes to treating neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Multiple Sclerosis, Huntington's disease, and amyotrophic lateral sclerosis. Tissue engineering mainly relies on three pillars: stem cells, scaffolds, and growth factors. Studies, mostly in animal models, indicated tissue engineering-based constructs could hugely improve the result of neurodegenerative disease treatment. The advent of new sources for harvesting stem cells, optimal methods for their differentiation, and advanced scaffolds led to improved treatment results for neurodegenerative diseases. However, the results of the studies were inconsistent; most of the studies were in vitro or in vitro; and clinical studies were limited. © Springer Nature Singapore Pte Ltd. 2024. All rights reserved.
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