Two Long Non-Coding Rnas, Cat179 and Cat1796, Differentiate Between Benign Prostate Hyperplasia and Prostate Cancer

Two Long Non-Coding Rnas, Cat179 and Cat1796, Differentiate Between Benign Prostate Hyperplasia and Prostate Cancer Publisher

Ebrahimi N¹ ; Amirmahani F¹ ; Akbari M² ; Ghahfarokhi AM³ ; Hajihashemi B⁴ ; Hamblin MR⁵

Show Affiliations

1. Genetics Division, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Iran
2. Department of Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Biology Department, Faculty of Science, Shahrekord University, Shahrekord, Iran
4. Department of Microbiology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
5. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa

Source: Archives of Biological Sciences Published:2021

Abstract

Several long non-coding RNAs (lncRNAs) have recently emerged as potential biomarkers in cancer biology. In the present study, we examined the expression of four lncRNAs (CAT179, CAT1796, PRCAT47, and CAT1066) to evaluate their ability to discriminate prostate tumors from benign prostate hyperplasia (BPH). Expression of these four lncRNAs was examined in 20 prostate cancer and 20 benign prostate hyperplasia (BPH) samples, as well as in urine samples (11 BPH, and 11 cancer). Total RNA was extracted for cDNA syntheses. The expression of the candidate lncRNAs was evaluated by quantitative real-time PCR (qRT-PCR). The lncRNAs CAT1796 and CAT179 were both upregulated in prostate cancer compared to BPH clinical samples (P<0.05). ROC curve analysis showed that CAT1796 had high sensitivity and specificity for diagnosis of prostate cancer (AUC=0.8151[95%CI 0.65-0.97]), suggesting that CAT1796 lncRNA could be a prostate cancer biomarker. © 2021. by the Serbian Biological Society

Related Docs

View other Related Docs

1. Long Non-Coding Rnas As Epigenetic Regulators in Cancer, Current Pharmaceutical Design (2019)

2. Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment, Cytokine and Growth Factor Reviews (2022)

3. Modulation of Long Non-Coding Rnas by Resveratrol As a Potential Therapeutic Approach in Cancer: A Comprehensive Review, Pathology Research and Practice (2023)

4. A Computational Framework to Infer Prostate Cancer-Associated Long Noncoding Rnas and Analyses for Identifying a Competing Endogenous Rna Network, Genetic Testing and Molecular Biomarkers (2021)

5. Expression Levels of Breast Cancer-Related Gas5 and Lsinct5 Lncrnas in Cancer-Free Breast Tissue: Molecular Associations With Age at Menarche and Obesity, Breast Journal (2018)

6. Constructing Mrna, Mirna, Circrna and Lncrna Regulatory Network by Analysis of Microarray Data in Breast Cancer, Gene Reports (2022)

7. Nanovaccines for Cancer Immunotherapy: Focusing on Complex Formation Between Adjuvant and Antigen, International Immunopharmacology (2023)

8. Long Noncoding Rnas and Exosomal Lncrnas: Classification, and Mechanisms in Breast Cancer Metastasis and Drug Resistance, Oncogene (2020)

Experts (# of related papers)

View all Related Experts

Hamid Reza Mirzaei (1)

Pantea Izadi (1)

Style	Citing Format
MLA	Ebrahimi N, et al.. "Two Long Non-Coding Rnas, Cat179 and Cat1796, Differentiate Between Benign Prostate Hyperplasia and Prostate Cancer." Archives of Biological Sciences, vol. 73, no. 3, 2021, pp. 399-406.
APA	Ebrahimi N, Amirmahani F, Akbari M, Ghahfarokhi AM, Hajihashemi B, Hamblin MR (2021). Two Long Non-Coding Rnas, Cat179 and Cat1796, Differentiate Between Benign Prostate Hyperplasia and Prostate Cancer. Archives of Biological Sciences, 73(3), 399-406.
Chicago	Ebrahimi N, Amirmahani F, Akbari M, Ghahfarokhi AM, Hajihashemi B, Hamblin MR. "Two Long Non-Coding Rnas, Cat179 and Cat1796, Differentiate Between Benign Prostate Hyperplasia and Prostate Cancer." Archives of Biological Sciences 73, no. 3 (2021): 399-406.
Harvard	Ebrahimi N et al. (2021) 'Two Long Non-Coding Rnas, Cat179 and Cat1796, Differentiate Between Benign Prostate Hyperplasia and Prostate Cancer', Archives of Biological Sciences, 73(3), pp. 399-406.
Vancouver	Ebrahimi N, Amirmahani F, Akbari M, Ghahfarokhi AM, Hajihashemi B, Hamblin MR. Two Long Non-Coding Rnas, Cat179 and Cat1796, Differentiate Between Benign Prostate Hyperplasia and Prostate Cancer. Archives of Biological Sciences. 2021;73(3):399-406.
BibTex	@article{ author = {Ebrahimi N and Amirmahani F and Akbari M and Ghahfarokhi AM and Hajihashemi B and Hamblin MR}, title = {Two Long Non-Coding Rnas, Cat179 and Cat1796, Differentiate Between Benign Prostate Hyperplasia and Prostate Cancer}, journal = {Archives of Biological Sciences}, volume = {73}, number = {3}, pages = {399-406}, year = {2021} }
RIS	TY - JOUR AU - Ebrahimi N AU - Amirmahani F AU - Akbari M AU - Ghahfarokhi AM AU - Hajihashemi B AU - Hamblin MR TI - Two Long Non-Coding Rnas, Cat179 and Cat1796, Differentiate Between Benign Prostate Hyperplasia and Prostate Cancer JO - Archives of Biological Sciences VL - 73 IS - 3 SP - 399 EP - 406 PY - 2021 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract