Asgr1 But Not Foxm1 Expression Decreases in the Peripheral Blood Mononuclear Cells of Diabetic Atherosclerotic Patients

Asgr1 But Not Foxm1 Expression Decreases in the Peripheral Blood Mononuclear Cells of Diabetic Atherosclerotic Patients Publisher Pubmed

Hamledari H¹ ; Sajjadi SF¹ ; Alikhah A¹ ; Boroumand MA² ; Behmanesh M¹

Show Affiliations

1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
2. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Diabetes and its Complications Published:2019

Abstract

Background: The ASGR1 was recently shown to play a key role in the development of coronary artery disease (CAD), but its exact mechanism of action in the CAD pathogenesis is not yet known. This study evaluates the possible association between the expression level of ASGR1 and its downstream transcription factor FOXM1 in the inflammatory cells of peripheral blood (PBMC) and the pathogenesis of CAD in the Diabetic condition. Methods: Blood samples were taken from the candidates who had visited the Tehran Heart Center and had underwent diagnostic tests with respect to diabetes and CAD. The peripheral blood cells were harvested, RNA was extracted, and cDNA was synthesized. The qRT-PCR was performed on 79 cDNA samples taken from 49 CAD+ patients and 30 CAD- patients. Results: In this study, we observed a significant decrease of ASGR1 expression in the PBMC of CAD+ patients compared to the CAD- patients. We did not identify any considerable differences in the expression of FOXM1 in patients' subgroups with respect to the diabetes and CAD. Conclusion: The results of our study determine the association of ASGR1 expression and CAD pathogenesis. However, we do not know whether this result is the cause or the effect of CAD. © 2019 Elsevier Inc.

Related Docs

View other Related Docs

1. The Role of Lnc-Dc Long Non-Coding Rna and Socs1 in the Regulation of Stat3 in Coronary Artery Disease and Type 2 Diabetes Mellitus, Journal of Diabetes and its Complications (2018)

2. Modulation of Radiation-Induced Base Excision Repair Pathway Gene Expression by Melatonin, Journal of Medical Physics (2017)

3. Prospect and Competence of Quantitative Methods Via Real-Time Pcr in a Comparative Manner: An Experimental Review of Current Methods, Open Bioinformatics Journal (2018)

4. Noise and Silver Nanoparticles Induce Hepatotoxicity Via Cyp450/Nf-Kappa B 2 and P53 Signaling Pathways in a Rat Model, Toxicology and Industrial Health (2024)

5. Nutrient Sensing Pathway Genes Expression Dysregulated in Patients With T2dm and Coronary Artery Disease, Diabetes Research and Clinical Practice (2019)

6. Elevated Liver Enzymes and Cardiovascular Mortality: A Systematic Review and Dose-Response Meta-Analysis of More Than One Million Participants, European Journal of Gastroenterology and Hepatology (2019)

7. Time Course Study of Erk1/2 Activity and Cell Viability in Lipopolysaccharide Challenged Pc12 Cells, Physiology and Pharmacology (Iran) (2021)

8. Targeting the Braf Signaling Pathway in Cd133pos Cancer Stem Cells of Anaplastic Thyroid Carcinoma, Asian Pacific Journal of Cancer Prevention (2019)

Experts (# of related papers)

View all Related Experts

Mohammad Ali Boroumand (2)

Pantea Izadi (1)

Style	Citing Format
MLA	Hamledari H, et al.. "Asgr1 But Not Foxm1 Expression Decreases in the Peripheral Blood Mononuclear Cells of Diabetic Atherosclerotic Patients." Journal of Diabetes and its Complications, vol. 33, no. 8, 2019, pp. 539-546.
APA	Hamledari H, Sajjadi SF, Alikhah A, Boroumand MA, Behmanesh M (2019). Asgr1 But Not Foxm1 Expression Decreases in the Peripheral Blood Mononuclear Cells of Diabetic Atherosclerotic Patients. Journal of Diabetes and its Complications, 33(8), 539-546.
Chicago	Hamledari H, Sajjadi SF, Alikhah A, Boroumand MA, Behmanesh M. "Asgr1 But Not Foxm1 Expression Decreases in the Peripheral Blood Mononuclear Cells of Diabetic Atherosclerotic Patients." Journal of Diabetes and its Complications 33, no. 8 (2019): 539-546.
Harvard	Hamledari H et al. (2019) 'Asgr1 But Not Foxm1 Expression Decreases in the Peripheral Blood Mononuclear Cells of Diabetic Atherosclerotic Patients', Journal of Diabetes and its Complications, 33(8), pp. 539-546.
Vancouver	Hamledari H, Sajjadi SF, Alikhah A, Boroumand MA, Behmanesh M. Asgr1 But Not Foxm1 Expression Decreases in the Peripheral Blood Mononuclear Cells of Diabetic Atherosclerotic Patients. Journal of Diabetes and its Complications. 2019;33(8):539-546.
BibTex	@article{ author = {Hamledari H and Sajjadi SF and Alikhah A and Boroumand MA and Behmanesh M}, title = {Asgr1 But Not Foxm1 Expression Decreases in the Peripheral Blood Mononuclear Cells of Diabetic Atherosclerotic Patients}, journal = {Journal of Diabetes and its Complications}, volume = {33}, number = {8}, pages = {539-546}, year = {2019} }
RIS	TY - JOUR AU - Hamledari H AU - Sajjadi SF AU - Alikhah A AU - Boroumand MA AU - Behmanesh M TI - Asgr1 But Not Foxm1 Expression Decreases in the Peripheral Blood Mononuclear Cells of Diabetic Atherosclerotic Patients JO - Journal of Diabetes and its Complications VL - 33 IS - 8 SP - 539 EP - 546 PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract