Neuroscience-Informed Classification of Prevention Interventions in Substance Use Disorders: An Rdoc-Based Approach Publisher Pubmed



Rezapour T¹ ; Rafei P³ ; Baldacchino A⁴ ; Conrod PJ⁵ ; Dom G⁶ ; Fishbein DH^{7, 8} ; Kazemi A¹ ; Hendriks V^{9, 10} ; Newton N¹¹ ; Riggs NR¹² ; Squeglia LM¹³ ; Teesson M¹¹ ; Vassileva J¹⁴ ; Verdejogarcia A¹⁵ Show All Authors Show Affiliations
Source: Neuroscience and Biobehavioral Reviews Published:2024

Abstract

Neuroscience has contributed to uncover the mechanisms underpinning substance use disorders (SUD). The next frontier is to leverage these mechanisms as active targets to create more effective interventions for SUD treatment and prevention. Recent large-scale cohort studies from early childhood are generating multiple levels of neuroscience-based information with the potential to inform the development and refinement of future preventive strategies. However, there are still no available well-recognized frameworks to guide the integration of these multi-level datasets into prevention interventions. The Research Domain Criteria (RDoC) provides a neuroscience-based multi-system framework that is well suited to facilitate translation of neurobiological mechanisms into behavioral domains amenable to preventative interventions. We propose a novel RDoC-based framework for prevention science and adapted the framework for the existing preventive interventions. From a systematic review of randomized controlled trials using a person-centered drug/alcohol preventive approach for adolescents, we identified 22 unique preventive interventions. By teasing apart these 22 interventions into the RDoC domains, we proposed distinct neurocognitive trajectories which have been recognized as precursors or risk factors for SUDs, to be targeted, engaged and modified for effective addiction prevention. © 2024 Elsevier Ltd