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Levofloxacin-Halloysite Nanohybrid-Loaded Fibers Based on Poly (Ethylene Oxide) and Sodium Alginate: Fabrication, Characterization, and Antibacterial Property Publisher



Fatahi Y1, 2, 3 ; Sanjabi M4 ; Rakhshani A1 ; Motasadizadeh H1 ; Darbasizadeh B4 ; Bahadorikhalili S5 ; Farhadnejad H4
Authors

Source: Journal of Drug Delivery Science and Technology Published:2021


Abstract

The main aim of the present study was to fabricate levofloxacin (LEV)-loaded halloysite nanotube (HNT)/sodium alginate (SA)-poly (ethylene oxide) (PEO) nanocomposite fibrous mats and evaluate their drug release and antibacterial activity. LEV was incorporated into the lumen of HA nanotubes via cyclic vacuum pumping in/out process. Structure and morphology of HNT-LEV nanohybrid particles and HNT-LEV/SA-PEO nanocomposite fibers were characterized via X-ray diffractometer (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), thermogravimetric analysis (TGA), and fourier transform infrared (FT-IR) techniques. SEM images indicated that the addition of HNT-LEV nanohybrid particles and LEV into the fabricated nanofibers resulted in changing their average diameter. In-vitro release profile showed that LEV release from HNT-LEV/SA-PEO nanocomposite fibers slowly occurred. Their anti-bacterial activity was studied against S. aureus and E. coli and found that HNT-LEV/SA-PEO nanocomposite fibers show suitable antimicrobial activity. Sustained drug release profile and suitable anti-bacterial activity of HNT-LEV/SA-PEO nanocomposite fibers indicated that it was a good biomaterial for wound dressings. © 2021 Elsevier B.V.
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