Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives

Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives Publisher

Esmati N¹ ; Foroughian M¹ ; Saeedi M² ; Mahdavi M² ; Khoshneviszadeh M^{2, 3} ; Firuzi O³ ; Tanideh N³ ; Miri R³ ; Edraki N^{2, 3} ; Shafiee A² ; Foroumadi A^{1, 2}

Show Affiliations

1. Drug Design and Development Research Center, Tehran University of Medicinal Sciences, Tehran, Iran
2. Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran
3. Medicinal and Natural Product Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Journal of Heterocyclic Chemistry Published:2015

Abstract

Three-component reaction of 4-hydroxy-2H-benzo[h]chromen-2-one, aromatic aldehydes, and malononitrile in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) in ethanol at room temperature affords good yields of novel dihyrobenzo[h]pyrano[3,2-c]chromene derivatives. The synthesized compounds examined by MTT assays for cytotoxic activity in two human cancer cell lines (MOLT-4, HL-60). Most of the evaluated compounds showed low inhibitory activity against tumor cell line at micromolar concentrations. © 2014 HeteroCorporation.

Style	Citing Format
MLA	Esmati N, et al.. "Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives." Journal of Heterocyclic Chemistry, vol. 52, no. 1, 2015, pp. 97-104.
APA	Esmati N, Foroughian M, Saeedi M, Mahdavi M, Khoshneviszadeh M, Firuzi O, Tanideh N, Miri R, Edraki N, Shafiee A, Foroumadi A (2015). Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives. Journal of Heterocyclic Chemistry, 52(1), 97-104.
Chicago	Esmati N, Foroughian M, Saeedi M, Mahdavi M, Khoshneviszadeh M, Firuzi O, Tanideh N, et al.. "Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives." Journal of Heterocyclic Chemistry 52, no. 1 (2015): 97-104.
Harvard	Esmati N et al. (2015) 'Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives', Journal of Heterocyclic Chemistry, 52(1), pp. 97-104.
Vancouver	Esmati N, Foroughian M, Saeedi M, Mahdavi M, Khoshneviszadeh M, Firuzi O, et al.. Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives. Journal of Heterocyclic Chemistry. 2015;52(1):97-104.
BibTex	@article{ author = {Esmati N and Foroughian M and Saeedi M and Mahdavi M and Khoshneviszadeh M and Firuzi O and Tanideh N and Miri R and Edraki N and Shafiee A and Foroumadi A}, title = {Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives}, journal = {Journal of Heterocyclic Chemistry}, volume = {52}, number = {1}, pages = {97-104}, year = {2015} }
RIS	TY - JOUR AU - Esmati N AU - Foroughian M AU - Saeedi M AU - Mahdavi M AU - Khoshneviszadeh M AU - Firuzi O AU - Tanideh N AU - Miri R AU - Edraki N AU - Shafiee A AU - Foroumadi A TI - Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives JO - Journal of Heterocyclic Chemistry VL - 52 IS - 1 SP - 97 EP - 104 PY - 2015 ER -

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