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Synthesis and Evaluation of Multi-Wall Carbon Nanotube-Paclitaxel Complex As an Anti-Cancer Agent



Ghasemvand F1 ; Biazar E2 ; Tavakolifard S3 ; Khaledian M2 ; Rahmanzadeh S1 ; Momenzadeh D4 ; Afroosheh R2 ; Zarkalami F2 ; Shabannezhad M2 ; Tackallou SH5 ; Massoudi N6 ; Keshel SH7, 8
Authors
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Authors Affiliations
  1. 1. Enzyme Technology Lab, Genetics and Metabolism Research Group, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
  3. 3. Department of Chemistry, Science and Research Branch, Islamic Azad University, Yazd, Iran
  4. 4. Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biology, Garmsar Branch, Islamic Azad University, Garmsar, Iran
  6. 6. Department of Anesthesiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Proteomics Research center, Shahid Beheshti University of medical sciences, Tehran, Iran
  8. 8. Stem cell preparation unit, Eye Research center, Farabi Eye Hospital, Tehran University of medical sciences, Tehran, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2016

Abstract

Aim: The aim of this study was to design multi-walled carbon nanotubes (MWCNTs) loaded with paclitaxel (PTX) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer. Background: Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading. Patients and methods: In this study, multi-walled carbon nanotubes (MWCNTs) pre-functionalized covalently with a paclitaxel (PTX) as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope (SEM), particle size analyzer and cellular analyses. Results: A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line. Conclusion: According to results, our simple method can be designed a candidate material for chemotherapy. It has presented a few bio-related applications including, their successful use as a nano-carriers for drug transport. © 2016 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
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