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Investigation of Properties of Chemically Cross-Linked Silk Nanofibrous Mat As a Nerve Guide Publisher



Ebrahimi M1 ; Ai J1 ; Biazar E2 ; Faridimajidi R3 ; Hajati J4 ; Ebrahimibarough S1 ; Heidari K S5
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biomaterials Engineering, Islamic Azad University, Tonekabon, Iran
  3. 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Medicine, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Translational Ophthalmology Research Centre (TORC), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Materials Technology Published:2017


Abstract

The aim of this study was to modify a nanofibrous silk mate with a chemically cross-linker. The nanofibrous mats designed by electrospinning method, then were modified using chemically cross-linker of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) in the presence of N-hydroxysuccinimide (NHS). The samples evaluated by microscopic, mechanical analyses, and cell culture assays with Schwann cells. Results of analyses showed a good resilience and compliance with chemically cross-linker. Cellular experiments showed a suitable cell adhesion and growth for the cross-linked mats without any toxicity. This modified mat appears to have the right organisation for testing in vivo special nerve tissue regeneration. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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