Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors

Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors Publisher

Asadipour A² ; Noushini S³ ; Moghimi S³ ; Mahdavi M⁴ ; Nadri H⁵ ; Moradi A⁵ ; Shabani S³ ; Firoozpour L³ ; Foroumadi A^{1, 2}

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1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
3. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences Published:2018

Abstract

An efficient aldol condensation/click reaction sequence is employed for the synthesis of chalcone-triazole-based derivatives in moderate to good yields. The ability of target compounds to inhibit 15-lipoxygenase enzyme was investigated and moderate to low inhibitory activities were observed for the synthesized compounds. © 2018 Walter de Gruyter GmbH, Berlin/Boston.

Style	Citing Format
MLA	Asadipour A, et al.. "Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 73, no. 2, 2018, pp. 77-83.
APA	Asadipour A, Noushini S, Moghimi S, Mahdavi M, Nadri H, Moradi A, Shabani S, Firoozpour L, Foroumadi A (2018). Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 73(2), 77-83.
Chicago	Asadipour A, Noushini S, Moghimi S, Mahdavi M, Nadri H, Moradi A, Shabani S, Firoozpour L, Foroumadi A. "Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences 73, no. 2 (2018): 77-83.
Harvard	Asadipour A et al. (2018) 'Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors', Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 73(2), pp. 77-83.
Vancouver	Asadipour A, Noushini S, Moghimi S, Mahdavi M, Nadri H, Moradi A, et al.. Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences. 2018;73(2):77-83.
BibTex	@article{ author = {Asadipour A and Noushini S and Moghimi S and Mahdavi M and Nadri H and Moradi A and Shabani S and Firoozpour L and Foroumadi A}, title = {Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors}, journal = {Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences}, volume = {73}, number = {2}, pages = {77-83}, year = {2018} }
RIS	TY - JOUR AU - Asadipour A AU - Noushini S AU - Moghimi S AU - Mahdavi M AU - Nadri H AU - Moradi A AU - Shabani S AU - Firoozpour L AU - Foroumadi A TI - Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences VL - 73 IS - 2 SP - 77 EP - 83 PY - 2018 ER -

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